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凝血酶激活的纤溶抑制物基因多态性及其与血栓性疾病关系的研究进展

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摘要 凝血酶激活的纤溶抑制物(thrombin-activatable fibrinolysis inhibitor,TAFI)属于金属羧肽酶家族成员,最初于1989年由Hendriks等首先在血清中发现,Boffa和Koschinsky于1995年发现TAFI被凝血酶激活后具有抑制纤溶酶的活性,且证明它与之前不同命名的血浆羧基肽酶原B、羧基肽酶原U和羧基肽酶原R为同一物质,现已统一命名为TAFI。
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2008年第9期1066-1069,共4页 Chinese Journal of Laboratory Medicine
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参考文献32

  • 1Boffa MB, Koschinsky ML. Curiouser and curiouser: recent advances in measurement of thrombin-activatable fibrinolysis inhibitor (TAFI) and in understanding its molecular genetics, gene regulation, and biological roles. Clin Biochem, 2007, 40 :431-442.
  • 2Henry M, Aubert H, Morange PE, et al. Identification of polymorphisms in the promoter and the 3' region of the TAFI gene: evidence that plasma TAFI antigen levels are strongly genetically controlled. Blood ,2001,97 : 2053-2058.
  • 3Frere C, Morange PE, Saut N, et al. Quantification of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism effects on plasma levels of TAFI measured with assays insensitive to isoform-dependent artefact. Thromb Haemost, 2005, 94:373- 379.
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  • 5Franco RF, Fagundes MG, Meijers JC, et al. Identification of polymorphisms in the 5'-untranslated region of the TAFI gene.. relationship with plasma TAFI levels and risk of venous thrombosis. Haematologica, 2001,86:510-517.
  • 6Bladbjerg EM, de Maat MP, Christensen K, et al. Genetic influence on thrombotic risk markers in the elderly--a Danish twin study. J Thromb Haemost, 2006,4:599-607.
  • 7Morange PE, Henry M,Frere C, et al. Thr325IIe polymorphism of the TAFI gene does not influence the risk of myocardial infarction. Blood, 2002,99 : 1878-1879.
  • 8Schneider M, Boffa M, Stewart R, et al. Two naturally occurring variants of TAFI ( Thr-325 and Ile-325 ) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme. J Biol Chem, 2002, 277:1021-1030.
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