摘要
目的:探讨原发性胆囊癌(PGC)组织中癌症高表达蛋白(Hec 1)的表达与浸润、转移及预后的关系。方法:首先,随机选取PGC患者108例,以慢性胆囊炎患者15例为对照,应用SABC免疫组化方法检测Hec 1蛋白的表达。其次,对108例PGC患者中的96例进行术后5年的随访,分析Hec 1与PGC患者预后的关联。结果:Hec 1蛋白的表达与PGC组织的临床病理学特征及患者的预后均有密切的关系。在发生淋巴道转移及低分化的肿瘤组织中,Hec 1蛋白高表达。随着Nevin分级的加重,Hec 1蛋白的阳性表达率明显增加(P<0.05)。此外,Hec 1蛋白阳性表达的PGC患者的5年生存率明显低于阴性表达的患者(P<0.01)。结论:Hec 1蛋白可能与PGC的发生、浸润、转移有关;联合应用Hec 1蛋白阳性表达率与其临床病理学分级,有助于正确判断患者的预后。
AIM： To investigate the relationship between the expression of highly expressed protein in cancer （Hec 1 ） and infiltration, metastasis and prognosis of human primary gallbladder carcinoma （ PGC ）. METHODS： The expression of Hec 1 in was detected 108 patients with PGC by SABC immunohistochemistry with 15 cases of chronic cholecystitis as control. Then, a 5 year follow-up was carnedout in 96 out of 108 patients to analyze the correlation between Hec 1 and prognosis of the patients. RESULTS： The clinical pathological characteristics of PGC and clinical outcome of the patients were associated with the expression of Hec 1. Hec 1 was highhy expressed in cancer tissues with lymph node metastasis and poor differentiation. Especially, a statistical correlation was found with more advanced Nevin stages of PGC （ P 〈 0.05 ）. Moreover, the 5-year survival rate of the patients with PGC whose expression of Hec t was positive was significantly lower than that of the patients without Hec 1 expression （ P 〈 0. 01 ）. CONCLUSION： Hec 1 may be associated with the development, infiltration and metastasis of PGC. The combination of Hec 1 expression in cancer tissues with clinical staging may faliliate the auurate predication of patients＇ prognosis.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2008年第9期910-912,共3页
Chinese Journal of Cellular and Molecular Immunology
基金
国家"十五"攻关课题(2001BA703BO)
湖南省自然科学基金资助项目(04JJ3100)
湖南省科委课题(05SK3052)
关键词
Hec1
原发性胆囊癌
临床病理学
预后
Hec 1
primary gallbladder carcinoma
clinical pathology
prognosis
