摘要
目的探讨3种术前治疗方法在Ⅰb—Ⅱb期宫颈癌治疗中的作用。方法92例Ⅰb～Ⅱb期宫颈癌．按术前治疗方式分为3组。放疗组49例，术前行后装放疗，剂量为1500～2400cGy；化疗组17例，行新辅助化疗1-2个疗程（PVB或DF方案）；放化疗组26例，先行化疗1个疗程，后装放疗1000—2000cGy；所有患者治疗后均行宫颈癌根治术。结果化疗组和放化疗组的局部肿瘤完全缓解率与放疗组比较有显著性差异（P〈0．001）；化疗组盆腔淋巴结转移率最低（P〈0．01）；3组术中出血量、手术时间比较无显著性差异（P〉0．05）。结论新辅助化疗能减少盆腔淋巴结转移：放化疗有协同作用．对局部晚期宫颈癌可以迅速缩小肿瘤．降低临床期别．增加手术机会．改善生存治疗。
Objective This study was aimed to investigate clinical significance of three preoperative combined treatments for cervical carcinoma in stage Ⅰ b - Ⅱb. Methods Ninety-two cases of cervical carcinoma in stage Ⅰ b - Ⅱb were divided into three group by different preoperative treatments. Forty-nine cases were preoperatively treated by radiotherapy with 1 500 - 2 400 cGy （ radiotherapy group）. Seventeen cases were treated by one to two courses of chemotherapy with PVB or DF regimen （ chemotherapy group）. Twenty-six cases were treated by radiotherapy of 1 000 - 2 000 cGy after one course of chemotherapy （ chemo-radiotherapy group）, All patients were then treated by radical hysterectomy. Results The complete remission rates of local tumor in chemotherapy group and chemo-radiotherapy group were significantly higher than that in radiotherapy group （ P 〈 0.001 ）, The metastasis rate of pelvic lymph node in chemotherapy group was the lowest among three groups （P 〈0. 01 ）, No significant differences were found in the amount of bleeding and the time of operation among three groups （ P 〉 0. 05 ）. Conclusion Preoperative chemotherapy is helpful to reduce the metastasis of pelvic lymph node. Preoperative chemotherapy and radiotherapy can effectively reduce the tumor volume, downstage the tumor and provide more possibilities for further surgical resection for locally advanced cervical carcinoma.
出处
《实用癌症杂志》
2008年第5期507-509,共3页
The Practical Journal of Cancer
关键词
宫颈癌
放射治疗
化学治疗
Cervical carcinoma
Radiotherapy
Chemotherapy
