摘要
经皮冠状动脉支架置入后,对血管壁刺激以及置入过程中造成血管内膜损伤、冠状动脉斑块破裂,导致血小板和炎症细胞聚集、浸润,释放各种生长因子,促进血管收缩和平滑肌细胞由中膜迁移到内膜并增殖,促进内膜增厚,形成血栓而致支架内再狭窄的发生。药物洗脱支架能给局部组织提供足够的治疗药物浓度,又避免了由于血药浓度过高而引起的全身毒副作用,有抗血管重塑和抗增殖作用,使血管再狭窄率降低到10%。药物涂层支架和药物洗脱支架降低了支架置入后血管内再狭窄率,生物可降解支架已成为目前研究关注的焦点和热点。
Following percutaneous coronary artery implantation, stimulation to vascular wall, vascular intimal injury and plaque disruption of the coronary artery can induce aggregation and infiltration of blood plaque and inflammatory cells, which release various growth factors, improve vasoconstriction, and promote immigration from media area to intimal area and proliferation of smooth muscle cells, accelerate intimal thickening, resulting in thrombus and restenosis in stent. Drug-eluting stent provides enough drug concentration for local tissues, avoids general side effects induced by high plasma concentrations of drugs, has effects against vessel remodeling and proliferation, and reduces restenosis rate of vessels by 10%. Drug eluting stent and drug-eluting stent decrease vascular restenosis rate after stent implantation. Biodegradable stent has been a key hot point in present research.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第35期6931-6934,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
