摘要
目的:观察降脂宁肝胶囊对大鼠脂肪肝的治疗作用并初步探讨其作用机制。方法:以高脂饲料并灌服乙醇6周造成大鼠脂肪肝模型,分为降脂宁肝胶囊高、中、低剂量组、东宝肝泰组、自然恢复组、模型组和正常组等7组,连续给药4周后,检测有关指标。结果:降脂宁肝胶囊组与自然恢复组比较,血液中ALT、CHOL和TG水平均显著降低(P<0.01或P<0.05);肝组织CHOL、TG、MDA、GSH水平均有显著改善(P<0.01或P<0.05),且存在量效关系,高剂量组的作用程度与东宝肝泰组相当;肝脏脂变程度显著减轻(P<0.01)。结论:降脂宁肝胶囊对大鼠脂肪肝有较好的治疗作用,其机制可能与降低血脂及抗脂质过氧化有关。
Objective： To observe the therapeutical effect of Jiangzhi Ninggan capsule on rats with fatty liver disease, and to explore the mechanism of it. Methods ： The rat models with fatty liver disease were established by feeding on high fat diet combined with ethanol via garage for 6 weeks. Then the rats were random divided into seven groups ：Jiangzhi Ninggan capsule groups （high dose,middle dose,low dose）, Dongbao C, antai pill group, natural recovery group, model group and control group. 4 weeks later, Liver pathologic changes were observed together with the activity of serum ALT, AST, the blood lipid, and the content of liver MDA,GSH,TG,CHOL. Results： Compared with the natural recovery group, the level of ALT,CHOL and TG in blood of Jiangzhl Ninggan capsule groups were reduced significantly （respectively, P 〈 0.01 ; P 〈 0.05 ） , and the content of CHOL,TG, MDA, GSH in liver tissue were ameliorated （respectively, P 〈 0. 01 ; P 〈 0.05）, furthermore it show dose -effect relation, the effect of high dose group was correspond with Dongbao Cantai pill group ; The hepatic steatosis degree were lighten obviously（ P 〈 0.01 ）. Conclusion ： Jiangzhi Ninggan capsule had good effect on fatty liver disease. This may be due to its effects in decreasing blood lipid and prevention of lipid peroxidation.
出处
《辽宁中医杂志》
CAS
北大核心
2008年第9期1420-1422,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省科技计划资助项目(2008B030301160)
关键词
降脂宁肝胶囊
大鼠
脂肪肝
实验研究
中医药疗法
Jiangzhi Ninggan capsule
rats
fatty liver disease
experimental study
treatment of TCM
