摘要
目的采用Ｌｅｗｉｓ肺癌来验证血管生成抑制剂ＴＮＰ－４７０对肿瘤生长和转移的抑制作用。方法将Ｌｅｗｉｓ肺癌细胞接种于Ｃ５７ＢＬ小鼠皮下（２．４×１０６／鼠）。将２０只小鼠随机分成对照组和治疗组，自第２天起分别给予溶剂（３％酒精）０．２ｍｌ和ＴＮＰ－４７０（４０ｍｇ／ｋｇ），隔天给药１次，共８次。第２２天时，测定对照组和治疗组的皮下瘤重及肺转移率，分别进行ｔ检验和χ２检验。结果两组皮下瘤重分别为３．７７±１．０５ｇ和１．９８±０．９６ｇ（Ｐ＝０．０００９）；两组肺转移率分别为８０％和３０％（Ｐ＝０．０３）。结论血管生成抑制剂ＴＮＰ－４７０能明显抑制Ｌｅｗｉｓ肺癌的生长和转移。
Objective The inhibition effect of angiogenesis inhibitor TNP 470 on tumor growth and metastasis was studied using Lewis lung carcinoma. Methods Lewis lung carcinoma cells(2.4×10 6/mouse) were inoculated subcutaneously to 20 mice, they were randomized into 2 groups. From the 2nd day, the treated group was given 40 mg/kg of TNP 470 SC q.o.d. (8 times) and the control group was given vehicle only (3% ethanol). On the 22nd day, the weight of the subcutanous tumors and the lung metastasis rates of the 2 groups were detected. The results were analysed by Student t and χ 2 test. Results The tumor weight of the control and treated group was 3.77±1.05 g and 1.98±0.96 g,respectively ( P =0.0009). The lung metastasis rate of the control and treated group was 80%(8/10) and 30%(3/10),respectively ( P =0.03). Conclusion These results suggest that the angiogenesis inhibitor TNP 470 has a strong inhibitory effect both on growth of the primary tumor and metastasis of Lewis lung carcinoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1997年第5期333-335,共3页
Chinese Journal of Oncology
