摘要
目的：确定表阿霉素骨水泥经皮介入治疗小鼠移植瘤的抗肿瘤效应．方法：３４只小鼠，体重１７～１８ｇ．Ｓ１８０肉瘤细胞１×１０７个皮下成瘤后随机分两组，１７只为治疗组，每个瘤块内注入含表阿霉素约１ｍｇ骨水泥０．５ｍｌ．另１７只为对照组，瘤块内注入单纯骨水泥０．５ｍｌ．每组取１０只动物记录肿瘤大小变化及观察存活期；余７只作病理学检查．结果：治疗组中，肿瘤体积在１～１０ｄ内逐日缩小，而对照组中肿瘤体积仍继续增大；治疗组动物存活期显著长于对照组（Ｐ＜０．０１）．病理检查发现治疗组水泥块周围瘤组织大片状坏死．结论：表阿霉素骨水泥介入治疗Ｓ１８０肿瘤具有显著的抗肿瘤效应．
Objective: The anti tumor effects of pharmorubicin bone cement by percutaneous interventional technique were evaluated. Methods: 1×10 7 S180 cells was injected subcutaneously into 34 mice each. Seven days later, the mice were divided into two groups randomly. In the treatment group, 0.5 ml bone cement that contained 1 mg pharmorubicin was injected into tumor tissue of every mouse. The change of tumor size, the pathological examination and the living time of mouse were observed. Results: In treatment group, the tumor size reduced gradually in 10 days. In control group, the tumor size still kept on enlarging. The living time of treatment group was significantly longer than control group ( P <0.01). The pathological examination found that the tumor tissue around bone cement presented necrosis. Conclusion: The results suggest that the pharmorubicin bone cement may have significant anti tumor effects on S180 sarcoma by percutaneous interventional technique.
出处
《第四军医大学学报》
1997年第5期421-423,共3页
Journal of the Fourth Military Medical University
