摘要
目的评价中孕超声筛查及羊水穿刺诊断胎儿染色体异常的临床应用价值。方法16例超声筛查可疑染色体异常中的12例及288例有产前诊断指征的孕妇在超声引导下抽取羊水检查染色体核型。结果16例超声筛查可疑染色体异常,检出异常染色体7例,检出率43.8%;羊水穿刺均一次成功,288例羊水细胞培养成功率97.9%,检出异常染色体17例,检出率6.0%。超声筛查异常、孕妇血清学筛查异常、不良孕产史等是有效的羊水穿刺指征,其中超声筛查异常染色体异常检出率明显高于其它组。结论中孕超声筛查是有效的产前诊断指征,有助于及时发现胎儿染色体异常,并在超声引导下羊水穿刺进一步明确诊断。
Objective： To evaluate the role of ultrasound sereening in the seeond trimester and Pereutaneous ultrasound -moni- tored amnioeentesis in diagnosis of fetal ehromosomal abnormalities. Methods ： Pereutaneous ultrasound - monitored amnioeentesis was performed on 12 of 16 suspieious fetal ehromosomal abnormalities and 288 pregnant women with indieantions for prenatal diagnosis to deteet karyotype of the fetus. Results： 7 ehromosomal abnormalities were deteeted in the 16 suspieious fetal ehromosomal abnormalities, and the detection rate of the ehromosomal abnormality was 43.8%. All the eases were punetured sueeessfully. Preeutaneous ultro- sound - monitored amnioeentesis was performed in 288 pregnant women. The arehievement rate of the amniotie fluid was 97.9% , and the deteetion rate of the ehromosomal abnormality was 6. 0%. The valid indieations of the puneture ineluded the abnormal fetus of ultro- sound sereening, the abnormal serology sereening results of pregnant women, the history of abnormal deliveries, the first of whieh was higher than the other indications at the detection of the chromosomal abnormality. Conelution： Ultrasound screening and Pereutaneous ultrasound - monitored amnioeentesis prove to be valid in the prenatal diagnosis, and ultrosound detection of abnormal fetus indicates the possibility of the fetal chromosomal abnormality.
出处
《中国优生与遗传杂志》
2008年第9期45-46,共2页
Chinese Journal of Birth Health & Heredity
关键词
超声
筛查
羊水穿刺
胎儿
染色体异常
Ultrosonography
Ultrosound screeningi Amniocentesis
Fetus
Chromosome abnormalities
