摘要
目的建立孕羊体外循环过程中胎羊有创监测模型，探讨母体体外循环对胎儿温度、血流动力学的影响。方法20头健康孕羊随机分为对照组、常温组、浅低温组和中低温组4组，每组5头。常规建立体外循环，转流降温。监测孕羊和胎羊的温度、心率、平均动脉压。结果中低温组1头孕羊转流后发生室颤导致孕羊和胎羊死亡。降温期胎羊温度始终高于孕羊的温度。复温期孕羊、胎羊温度回升，转流结束后胎羊温度低于孕羊温度。降温期胎羊心率逐渐减慢，血压下降，复温期逐渐恢复正常。结论母体体外循环影响胎儿温度、血压和心率，但变化是可逆的。母体常温或浅低温体外循环对胎儿的影响最小，临床上可以安全应用。
Objective To establish animal model for invasive monitoring in fetus during maternal cardiopulmonary bypass and to evaluate fetal-maternal teraperature relationship and fetal cardiovascular response during maternal cardiopulmonary bypass in pregnant ewes. Methods The atemal cardiopulmonary bypass was established, reaching different levels of maternal hypothertnia. 20 pregnant ewes were divided into 40 groups, including normothennic group, mild hypothennic group, moderate hypothennic group and control group. Hypothermic levels were maintained for 20 minutes, then the rewarming phase was started. Fetal and maternal temperature, blood pressure, heart rate were evaluated at different levels of hypothennia and during recovery. Results One ewe died of ventricular filbrillation in moderate hypothenni group, and the other ewes and fetuses survived. Maternal temperature was always lower than fetal temperature during cooling; during rewanning the gradient was inverted. The start of cardiopulmonary bypass and cooling was associated with transient fetal tachycardia; then, both fetal heart rate and blood pressure progressively decreased. Conclusion Maternal hypothermic cardiopulmonary bypass was associated with reversible modifications in fetal temperature, cardiovascular parameters. The application of normothennic or mild hypothennic perfusion is safe to the fetus and mother.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2008年第4期268-270,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
妊娠
心肺转流术
模型
动物
Pregnancy Cardiopuhnonary bypass Models Animal
