摘要
目的研究术前化疗在治疗小儿成神经细胞瘤中的作用。方法对照研究应用术前化疗后切除的成神经细胞瘤２１例，观察尿香草扁桃酸（ＶＭＡ）、ＤＮＡ图象分析和ＭＹＣＮ基因变化。结果手术切除率为９５５％，平均生存时间为２８１±１０２ｍｏ，显著高于一期手术组的８８±６８ｍｏ（Ｐ＜００１）。化疗后尿ＶＭＡ较化疗前降低（Ｐ＜００１）。化疗后肿瘤细胞ＤＮＡ指数下降，Ｇ０＋Ｇ１时相比例升高，ＭＹＣＮ基因表达明显抑制。结论术前化疗具有诱导成神经细胞瘤细胞凋亡和促使肿瘤细胞增殖活性降低的作用。
PURPOSE To study the effectiveness of preoperative chemotherapy in neuroblastoma treatment.METHODS 21 cases of neuroblastoma were treated by preoperative chemotherapy. The urine VMA, DNA image analysis and MYCN gene were studied.RESULTS The resectability rate is 95.5%, the mean survival time 28.1±10.2 months, both noticeably higher than the operation only group(P<0.01). The DNA index of the tumor cells was reduced after chemotherapy as well as the proportion of G0+G1 phase. The expression of MYCN gene was markedly inhibited.CONCLUSIONS Preoperative chemotherapy can induce neuroblastoma cell apoptosis and reduce the tumor cell proliferation rate.
出处
《中国癌症杂志》
CAS
CSCD
1997年第4期283-285,共3页
China Oncology
