摘要
环氧合酶(COX)是合成前列腺素(PG)过程中一个重要的限速酶,有COX-1、COX-2和COX-3三种异构体。近年的研究表明,COX-2与非酒精性脂肪性肝病(NAFLD)的发生发展密切相关。此文就COX-2与NAFLD的关系以及COX-2抑制剂治疗NAFLD的研究进展作一综述。
Cyclooxygenase （COX） is a key enzyme in the synthesis of prostaglandins （ PG ） . Three isoforms of this enzyme have been identified： COX-1, COX-2 and COX-3. Recent studies have suggested that COX-2 may play an important role in the growth and development of non-alcoholic fatty liver disease （NAFLD）. In this article, the relationship between COX-2 and NAFLD as well as the treatment of NAFLD by COX-2 inhibitors were reviewed.
出处
《国际内科学杂志》
CAS
2008年第8期477-480,共4页
International Journal of Internal Medicine
