摘要
全身80%-90%的巨噬细胞为位于肝血窦内的Kupffer细胞(KC).KC激活后将诱发TNF-α、前列腺素、一氧化氮及氧自由基等各种炎症细胞因子的大量形成,除导致自身功能形态发生改变外,还直接影响邻近的肝细胞,血管内皮细胞以及位于血窦腔内的中性粒细胞等多种细胞,进而启动热缺血或冷缺血后肝脏的缺血再灌注损害(ischemia reperfusion injury,IRI).本文拟就KC与肝脏IRI的关系进行综述,以期为IRI的防治寻求到适宜的治疗靶点及途径.
Kupffer cells, residing within the lumen of liver sinusoids, constitute 80%-90% of tissue macrophages present in the body. Upon activation Kupffer cells release various products, including cytokines, prostanoides, nitric oxide and reactive oxygen species. These factors regulate the phenotype of Kupffer cells themselves, and the phenotypes of neighboring cells, such as hepatocytes, stellate cells, endothelial cells and other immune cells that traffic through the liver. Therefore, Kupffer cells are intimately involved in the liver＇s response to warm or cold ischemia reperfusion injury （IRI）. This review the role of Kupffer cells in the pathogenesis of liver IRI to explore the reasonable therapeutic target.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第24期2741-2745,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助课题
No.30500473
中国博士后科学基金资助课题
No.20070411152
重庆市自然科学基金资助课题
No.2005BB5242~~
