摘要
目的观察雷贝拉唑、左氧氟沙星、阿莫西林三联疗法治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性消化性溃疡的疗效。方法随机将200例Hp阳性消化性溃疡患者分为A组和B组,A组,男61例,女39例;年龄(59±10)岁;十二指肠球部溃疡(DU)61例,胃溃疡(GU)39例,给予雷贝拉唑10mg、左氧氟沙星200mg及阿莫西林1 000mg,2次/d口服。B组,男58例,女42例;年龄(58±9)岁;DU59例,GU41例,给予奥美拉唑20mg、克拉霉素500mg及阿莫西林1 000mg,2次/d口服。疗程均为10d。疗程结束后4周复查胃镜及Hp。结果A、B二组抗Hp治疗结束后4周,Hp根除率各为91%、80%(P<0.05),溃疡的愈合率分别为94%、84%(P<0.05)。均无严重不良反应。结论雷贝拉唑、左氧氟沙星、阿莫西林新三联疗法具有Hp根除率高、不良反应少、溃疡愈合迅速、疗程短等优点,是目前治疗Hp阳性溃疡及根除Hp较为理想的方案。
Objective To observe the efficiency of the triple therapy regimens with rabeprazole, levofloxacin and amoxicillin in the treatment of Helicobacter pylori（Hp） - related ulcer. Methods 200 Hp - related ulcer patients were divided in to the group A and the group B randomly, [Group A, male 61 cases,female 39 cases,age （59 ±10）a , DU 61 cases, GU 39 cases] were treated with rabeprazole 10mg,levofloxacin 200mg and amoxillin 1 000mg po bid for 10 day. [Group B,male 58 cases, female 42 cases; age （58 ±9）a; DU 59 cases, GU 411 cases] were treated with omeprazole 20 mg,clarithromycin 500 mg and amoxillin 1000 mg, po,bid for 10 day. Four weeks later, Hp tests and endoscope were performed again. Results Hp eradication rate was 91% in group A and 80% in group B （P〈0.05）. The ulcer healing rate was 94% in group A and 84% in group B （P〈0.05）. without severe adverse reaction. Conclusion The triple therapy regimens with rabeprazole, levofloxacin and amoxicillin is effective in Hp eradication rate and the ulcer healing rate.
出处
《中国煤炭工业医学杂志》
2008年第9期1307-1308,共2页
Chinese Journal of Coal Industry Medicine
