摘要
对人体中一个新的乙肝表面抗原结合蛋白SBP(HBsAg Binding Protein)进行了组成和结构分析.利用免疫组化的方法检测了人脑、肝、前列腺、肌肉、胃以及睾丸等组织的SBP的表达情况,并利用ELISA方法测定了慢性乙型肝炎病人、乙肝康复者以及健康人血清中SBP的含量并作统计学分析.免疫组化结果显示SBP存在于包括肝组织在内的多种组织中.ELISA结果表明,慢性乙肝病人、乙肝康复者以及健康人血清中SBP含量存在显著差异,推测SBP可能与人体对乙肝病毒的易感及耐受有关.
By using immune tissue chemistry, the natural existence of SBP in various human tissues （brain, liver, prostate, muscle, stomach） was detected, and the quantity of SBP in the serum of chronic hepatitis B patients, healthy person and people recovered from hepatitis B was tested by ELISA, the results was then analysised by statistic method. Result of immune tissue chemistry showed that SBP exists in various human tissues ineluding liver, which indicated that SBP may be an assistant receptor of HBV, or it may be a soluble pattern recognizing receptor; results of ELLSA showed great difference of SBP quantity in the serum of chronic hepatitis B patients, healthy person and people who recovered from hepatitis B, it is speculated that SBP may be related with the fragility and tolerance against HBV.
出处
《复旦学报（自然科学版）》
CAS
CSCD
北大核心
2008年第3期325-328,335,共5页
Journal of Fudan University：Natural Science
基金
"863"高技术目标导向课题资助项目(2006AA02Z462)
