摘要
目的探讨阿立哌唑对首发精神分裂症认知功能康复的持续影响。方法48例首发精神分裂症患者以阿立哌唑治疗52周,治疗前后进行威斯康星卡片分类测验、持续操作试验、阳性与阴性症状量表评定,并与45例正常人对照。结果治疗组在治疗52周后PANSS量表各项指标分值均较治疗前有明显下降(P均<0.01);WCST总测验数、正确反应数、持续错误数、非持续错误数及CPT各项指标(分别为66.09±17.82、24.90±1.22、18.50±6.42、22.27±12.16、28.14±2.91)均较治疗前(分别为85.28±19.57、23.45±3.11、26.77±9.53、34.69±15.35、24.36±3.30)有显著性改善(P均<0.01);治疗组于治疗后在上述WCST(正确反应数除外)和CPT指标与对照组(分别为56.96±10.54、14.66±9.10、17.35±11.23、31.04±2.19)比较仍有显著性差异(P<0.05～0.01);PANSS总分、阳性症状分量表分、阴性症状分量表分的改善与WCST总测验数、持续错误数、非持续错误数呈正相关(r=0.386～0.482,P均<0.01),与CPT总分呈负相关(r=-0.377～-0.397,P均<0.01),一般精神病理分量表分与持续错误数呈正相关(r=0.410,P<0.01)。结论阿立哌唑对精神分裂症的认知功能障碍有持续改善作用,且认知功能的改善与精神症状的改善存在着明显相关。
Objective To explore the persistent effects of aripiprazole on rehabilitation of cognitive function in first-onset schizophrenia. Methods 48 patients with schizophrenia（treatment group） were assessed by Wisconsin Card Sorting test（WCST）,Continue performanee test （CPT） and Positive and Negative syndrome scale（PANSS） before and afler treatment by aripiprazole for 52 weeks. 45 health volunteers were assessed by WCST and CPT as control group. Results There were significant differences in scores of PANSS（all P〈 0.01 ）,significant differences in number of total trials of WCST,number of right,number of persisting errors,number of random errors and number of total CPT test between before（66.09 ± 17.82,24.90 ± 1.22,18.50 ± 6.42,22.27 ± 12.16,28.14 ± 2.91, respectively ） and after（ 85.28 ± 19.57,23.45 ± 3.11, 26.77±9.53,34.69 ±15.35,24.36±3.30, respectively） treatment in treatment group（ all P 〈 0.01 ）, but there were also significant differences in these indexes（despite of number of fight） belween the treatment group after accepting 52 weeks of treatment and the control group（56.96 ±10.54, 14.66± 9.10, 17.35± 11.23,31.04±2.19, respectively, P 〈 0.05-0.01 ）. Number of total WCST tests, number of persisting errors and number of random errors were all positively related to the scores of PANSS, the positive subscale and the negative subscale（r= 0.386 - 0.482, all P 〈 0.01 ）. but number of total trials of CPT was negatively related to them （r = -0.377 ～ -0.397,all P 〈 0.01 ）,and there was a positive relation between number of persisting errors and the factor of common psychopathology in PANSS（ r = 0.410, P 〈 0.01 ）. Conclusion Aripiprazole can persistently,improve the cognitive disorder in schizophrenia,and the improvement of cognitive function is related significantly to the degree of psychopathology.
出处
《中国现代医生》
2008年第25期20-22,共3页
China Modern Doctor
关键词
精神分裂症
阿立哌唑
认知功能
康复
神经心理学测验
Schizophrenia
Aripiprazole
Cognitive function
Rehabilitation
Neuropsychological test
