摘要
目的:合理应用糖皮质激素及嘌呤类似物治疗炎症性肠病。方法:复习文献,总结糖皮质激素及嘌呤类似物治疗炎症性肠病的适应证、用药时机、疗程、疗效及不良反应。结果及结论:糖皮质激素适用于氨基水杨酸制剂疗效不佳的轻、中型患者,尤其适用于重型活动期及暴发型患者;应根据患者炎症性肠病病变的程度和范围选择合适的剂量、给药方式,注意药品不良反应。嘌呤类似物主要适用于对糖皮质激素依赖的UC病例及维持缓解用药以及激素疗效不佳的轻、中度炎症、瘘管性病变以及激素依赖的CD病例。起效慢,不单独用于急性期的治疗;不良反应存在个体差异,用于维持缓解,宜长期用药。
OBJECTIVE： To use glucocorticoid and purine analogue rationally for the treatment of inflammatory bowel diseases. METHODS： The pertinent literature was reviewed, and the indications, medication time, course of treatment, curative effect and adverse drug reations of the glucocorticoid and purine analogue in the treatment of inflammatory bowel diseases were summarized. RESULTS ＆ CONCLUSION： Glucocorticoid is indicated for patients with mild or mediuim types of inflammatory bowel diseases who had a poor response to aminosalicylic acid, especially to severe type on active phase and fulminating type. The choice of dosage and route of administration should be based on the degree and extent of inflammatory bowel diseases, meanwhile, the adverse drugs reactions should be monitored. Purine analogue is indicated for glucocorticoid - dependent ulcerative colitis （UC） cases, maintainable remission, mild or mediuim types of inflammatory bowel diseases, fistula diseases, and hormone dependent Crohn＇s disease （CD） cases. Because of the slow onset of drug effect of purine analogue, which shouldn＇t be used alone for acute stage treatment; there was individual variation for its adverse drug reactions, and long - term medication is advisable for remission maintenance.
出处
《中国医院用药评价与分析》
2008年第8期569-571,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
炎症性肠病
溃疡性结肠炎
克罗恩病
糖皮质激素
嘌呤类似物
治疗学
Inflammatory bowel disease
Ulcerative colitis
Crohn ＇ s disease, Glucocorticoid
Purine analogue
Therapeutics
