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阿利新蓝染色检测急性早幼粒细胞白血病柴捆状Auer小体的研究 被引量:2

Research on detection of fascine shape Auer body in acute promyelocytic leukemia by alcian blue staining
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摘要 目的:研究阿利新蓝染色对急性早幼粒细胞白血病(APL)患者白血病细胞柴捆状Auer小体的显示情况。方法:随机选取23份APL患者骨髓涂片标本及23份急性髓细胞白血病(AML)非M3型骨髓涂片标本进行阿利新蓝染色,以瑞-吉染色为对照。结果:阿利新蓝染色检测APL柴捆状Auer小体阳性细胞的百分率显著高于瑞-吉染色(P<0.05),且形态上更易辨认。阿利新蓝染色对非APL的Auer小体不能显示。结论:阿利新蓝染色对APL患者骨髓涂片柴捆状Auer小体的显示优于瑞-吉染色,有助于为APL的诊断提供可靠形态学依据。阿利新蓝染色对非APL的Auer小体不能显示,有助于避免误诊APL。 Objective:To study the detection of fascine shape Auer body in acute promyelocytic leukemia by Al clan blue staining. Methods:Bone marrow samples from 23 patients with acute promyelocytic leukemia (APL) and 23 patients with acute myeloid leukemia (AML) were randomly chosen to stain by Alcian blue contrasted to Wright Giemsa stain. Results: Alcian blue staining had advantages on detecting fascine shape Auer body than Wright-Giemsa stain in APL but could not stain Auer body in non-APL AML. Conclusion: Alcian blue staining has advantages on detecting fascine shape Auer body than Wright Giemsa stain in APL thus it helps for supplying reli able data for diagnosis of APL. Alcian blue staining can not detect Auer body in non-APL AML thus helps for avoiding misdiagnosing APL.
出处 《临床血液学杂志》 CAS 2008年第4期353-355,共3页 Journal of Clinical Hematology
关键词 白血病 早幼粒细胞性 急性 AUER小体 Leukemia, promyelocytic, acute Auer body
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参考文献6

  • 1WANG Z Y,CHEN Z. Acute promyelocytic leukemia: from highly fatal to highly curable[J]. Blood, 2008, 111:2505-2515.
  • 2JEHN U,THIEL E. Auer bodies in acute lymphocytic leukaemia and B-cell lymphoma: Evidence for a com- mon progenitor of myeloid and lymphoid cells[J].? Ann Hematol, 1981,43:7-14.
  • 3KAZUTAKA KURIYAMA,MASAO TOMONAGA, TOHRU KOBAYASHI,et al. Morphological Diagnoses of the Japan Adult Leukemia Study Group Acute Myeloid Leukemia Protocols:Central Review[J]. Int J Hematol, 2001,73 : 93 - 99.
  • 4李早荣,王晓君,寿爽,吴秋花,孙长贵.Auer小体及富含Auer小体的早幼粒细胞白血病[J].现代检验医学杂志,2006,21(6):66-67. 被引量:9
  • 5李彦会,刘永春,史敏.三种阿利新蓝染色方法效果观察[J].河北医科大学学报,2005,26(6):464-464. 被引量:5
  • 6李顺义 李玉秀 殷玉敏.阿利新蓝染色在急性白血病诊断上的应用[J].中华血液学杂志,1983,4(2):112-112.

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