摘要
目的：评价成人特发性血小板减少性紫癜（ITP）对患者生活质量（QoL）的影响。方法：使用Medical Outcome Study SF-36 form（SF-36）中文版对中国医学科学院血液病医院236例成人ITP患者进行QoL调查。按照血小板计数，将患者分为3组[PLT〈30×10^9／L；PLT（30～100）×10^9／L；PLT〉100×10^9／L]。SF-36的8个维度作为测量结果：躯体健康（PF）；社会功能（SF）；躯体角色功能（RP）；躯体疼痛（BP）；心理健康（MH）；情绪角色功能（RE）；精力（VT）；总体健康（GH）。结果：在8个维度ITP患者和正常人相比SF-36 QoL均降低。在PF、RP、BP、GH、SF和RE等6个维度中QoL得分差异有统计学意义。急性ITP患者在GH、VT和RE3个维度与慢性患者相比QoL得分的差异有统计学意义。同时，在根据血小板计数分组的比较中，在PF、GH和SF3个维度显示了明显的差别。年龄是除了SF以外其他所有维度的负性预测因子。当前血小板计数是BP，SF和GH的负性预测因子。而且治疗费用也影响了QoL得分。对出血的恐惧作为主观指标对QoL有明显的负面影响。结论：成人ITP患者的QoL明显降低，年龄、血小板计数和出血的恐惧对QoL有明显的负面影响。本研究为ITP的临床研究提供了基于询证的证据。
Objective：The aim of this study is to assess the quality of life（QoL） of Chinese adults with idiopathic thrombocytopenic purpura（ITP）. Method：The Chinese（mainland） version of Medical Outcome Study SF-36 form（SF-36） Health Survey was used to measure health-related QoL in 236 adults with ITP in a cross-sectional study. According to the current platelet count, patients were subclassified to three groups： the first group（platelet count 〈30×10^9/L）, the second group （platelet count 30 - 100 ×10^9/L）, the third group （platelet count 〉 100×10^9/L）, respectively. Result：Comparison of SF-36 subscores of patients with ITP with healthy individuals revealed the reduction of QoL in all of the eight SF-36 dimensions. The difference on statistical significance presented in six of eight dimensions of SF-36 including physical functioning （PF）, role limitations due to physical problems, body pain, general health perception（GH）, social functioning（SF）, and role limitations due to emotional problems（RE） between the patients with ITP and the normal population （ P 〈0.01）. The acute ITP group showed better scores in three dimensions including GH, energy/vitality, and RE than chronic ITP group （ P 〈0. 01）. Meanwhile through classification with platelet count, three subgroups of patients also experienced significant differences in PF, GH, and SF from the eight dimensions. Age was a significant negative predictor of all eight dimensions other than the SF while current platelet count was a significant negative predictor of GH. Moreover, the treatment cost and family income also influenced the QoL scores. The subjective feeling of fear about bleeding had a detrimental impact on QoL. Conclusion：QoL was impaired in patients with ITP, especially in the acute patients. The platelet count and the feeling of fear about bleeding had a detrimental impact on QoL.
出处
《临床血液学杂志》
CAS
2008年第4期339-342,共4页
Journal of Clinical Hematology
基金
天津市自然科学基金重点项目资助(No:06YFJZJC01800)
公益性科研专项(No:200802031)
关键词
紫癜
血小板减少性
生活质量
SF-36
Idiopathic thrombocytopenic purpura
Health-related quality of lifei Short Form 36
