摘要
头孢克罗（ｃｅｆａｃｌｏｒ）是第一代的头孢类抗菌素，因其副作用小，抗菌活性高，易于口服等优点受到临床上的欢迎。近期国内亦有研制开发，为考察国内药品的临床效果，本文对国产口服头孢克罗胶囊的药效学参数和生物利用度进行了研究。结果表明，国产胶囊与进口同类产品相比，药动学参数之间无显著性差异，Ｃｍａｘ为１４．１０±２．８６，ｔｍａｘ＝０．７６±０．２６，与Ｌｉｌｙ公司药物相比，相对生物利用度为１．０１±０．１５。
The HPLC method for determining the cefaclor concentration of plasma was described in this paper. The pharmcokinetics parameters were measured and the relative bioavailabilities between domestic and imported cefaclor were compared. The results show that there are no notable difference existing among them.
出处
《河南科学》
1997年第3期330-332,共3页
Henan Science
