摘要
目的探讨辐射损伤后外周血及肝脏NO的变化。方法以9.0Gy电离辐射全身均匀照射NIH小鼠,然后立即置于室温环境中,并分别于照前,照后各不同时间点获取血清和肝细胞匀浆,分别测各自的NO浓度。结果大剂量电离辐射作用后,外周血血清和肝细胞匀浆中NO浓度均升高,但外周血NO浓度值在照后3h开始升高,而肝细胞匀浆在照后6h开始升高。结论电离辐射能引起小鼠外周血及肝脏中NO浓度增加,但不同组织的反应强度不一致。
Objective To study the effect of radiation injury on nitric oxide （NO） concentration in mouse peripheral blood and liver. Methods NIH mice were subjected to gamma-ray exposure at 9.0 Gy and transferred immediately in room temperature condition. NO concentrations in the liver and peripheral blood were examined before and at different time points after the exposure. Results Compared to that before exposure, NO concentration in the peripheral blood and liver significantly increased after gamma-ray exposure. NO concentration in the peripheral blood began to increase 3 h after the exposure, but that in the liver increased till 6 h after the exposure. Conclusions Radiation can cause the increase of NO concentration in the peripheral blood and liver, but different tissues may exhibit different response intensities to radiation.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第8期1405-1406,共2页
Journal of Southern Medical University
基金
广东省反恐技术研究科研项目基金(C2006n33761001)
广东省卫生厅医学科研基金(B2008098)
关键词
辐射损伤
NO
血清
肝脏
radiation injury
nitric oxide
serum
liver
