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嗅鞘细胞移植治疗帕金森叠加综合征1例

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摘要 患者,女,23岁,由北京西山医院神经疾病研究治疗中心诊断为帕金森叠加综合征。采用立体定向方法,将嗅鞘细胞移植到患者双额放射冠部位。患者术后当天诉右手可以握拳,语言较术前清晰,四肢肌张力较术前减低,第2天双侧下肢肌张力较术前减低,第3天语言较术前明显清晰,面部表情较术前丰富。国际统一的帕金森病评定量表评分显示,自嗅鞘细胞移植后4h开始,患者神经功能逐渐有部分改善,术后第14天总分由术前109分降至97分:其中言语表达2→1分,面部表情4→3分,强直项中:颈3→2右上肢3→2左上肢3→2右下肢3→1左下肢3→2,手指拍打实验:右手4→3左手4→3,手运动:右4→3左4→3。患者住院期间未发现任何不良事件。
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2008年第34期6799-6800,共2页 Journal of Clinical Rehabilitative Tissue Engineering Research
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  • 1Dib M.Amyotrophic lateral sclerosis Progress and prospects for treatment.Drugs2003; 63:289-310
  • 2Rowland LP,Shneider NA.Amyotrophic lateral sclerosis.N Engl J Med 2001; 344:1688-700
  • 3Bensimon G,Lacomblez L,Meininger V,et al.A controlled trial of riluzole in amyotrophic lateral sclerosis.N Engl J Med 1994; 330:585-91
  • 4Miller RG,Mitchell JD,Lyon M,et al.Riluzole for amyotrophic lateral sclerosis(ALS)/motor neuron disease(MND).Cochrane Database Syst Rev 2001;CD001447
  • 5Morrison KE.Therapies in amyotrophic lateral sclerosis-beyond riluzole.Curr Opin Pharmacol2002; 2:302-9
  • 6Franklin RJ,Gilson JM,Franceschini IA,et al.Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathin8 cell line into areas of demyelination in the adult CNS.Glia 1996; 17:217-24
  • 7Imaizumi T,Lankford KL,Burton WV,et al.Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord.Nat Biotechnol 2000; 18:949-53
  • 8Karo T,Honmou O,Uede T,et al.Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord.Glia 2000; 30:209-18
  • 9Li Y,Field PM,Raisman G.Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.Science 1997; 277:2000-2
  • 10Lu J,Feron F,Mackay-Sim A,et al.Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord.Brain 2002; 125:14-21

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