摘要
目的:对罗哌卡因硬膜外阻滞复合全麻的手术病人进行药代动力学研究。方法:选择12例上腹部手术病人,硬膜外腔注入0.5%罗哌卡因,并行全麻诱导,于输入罗哌卡因后1、10、20、30、45、60、75、90、120、150、180min分别从左桡动脉采血,用高效液相色谱仪测定罗哌卡因血药浓度,用DAS2.0药动学统计软件拟合房室模型,并计算各项药代动力学参数。结果:术中、术后均未见与罗哌卡因有关的不良反应,罗哌卡因的主要药代动力学参数:tmax为10min;Cmax为0.713mg/L;t1/2α为122min;t1/2β为190min;AUC0→180为(72±10)μg·mL-1·min-1。结论:复合全麻下罗哌卡因硬膜外阻滞药物代谢符合二室模型,安全性良好,镇痛效果满意。
AIM： To study the pharmacokinetics characteristics of patients who used ropivacaine epidural block with general anesthesia. METHODS： Twelve patients scheduled for upper abdominal surgery were included in this study. 0.5 % ropivacaine was injected into epidural space before general anesthesia. Blood samples were taken from left radial artery, at 1,10,20, 30,45,60,75,90,120,150 and 180 min after injecting ropivacaine. The plasma concentration of ropivacaine was dete,Tnined by HPLC. The Compartment model was fitted by DAS statistics software, and the pharmacokinetic parameters were calculated. RESULTS： There were no adverse effects about ropivacaine during and after operation. The main pharmacokinetic parameters were as follow： tmax was 10 min; Cmax was 0.713 mg/L; t1/2α was 122 min; t1/2β was 190 min;AUC0→180 was （72 ± 10） ug·mL^-1 ·min^-1. CONCLUSION： The concentration-time curves were fitted to two-compartment open pharmacokinetic model. 0.5% ropivacaine was proved to be safe, and it had good analgesia effect.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第7期809-812,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省嘉兴市科技局科技计划项目(2005AY3026)
关键词
罗哌卡因
药代动力学
硬膜外阻滞
复合全麻
ropivacaine
pharmacokinetics
epidural block
combined with general anesthesia
