期刊文献+

窄谱中波紫外线对银屑病患者肿瘤坏死因子和白介素-2的影响及疗效 被引量:6

暂未订购
导出
摘要 目的:观察窄谱中波紫外线(NB-UVB)治疗银屑病的疗效及探讨其作用机制。方法:随机将120例银屑病患者分为治疗组与对照组,治疗组用NB-UVB照射,对照组内服迪银片。两组均以一个月为1个疗程,2个疗程后进行疗效判定,检测患者治疗前后血清肿瘤坏死因子(TNF-α)和白介素-2(IL-2)的水平,并和正常对照组比较。结果:治疗组60例基本痊愈35例,显效12例,有效7例.无效6例,对照组60例基本痊愈24例,显效13例,有效8例,无效15例,治疗组基本痊愈率及总有效率均高于对照组(P<0.05)。二组治疗后TNF-α和IL-2较治疗前降低,治疗组优于对照组(P<0.05)。结论:NB-UVB是治疗银屑病的安全有效的方法,可能通过降低患者血清TNF-α和IL-2水平起作用。
出处 《岭南皮肤性病科杂志》 2008年第4期211-213,共3页 Southern China Journal of Dermato-Venereology
基金 广州市医药卫生科技资助项目(项目编号:2006-YB-149)
  • 相关文献

参考文献8

  • 1Ferenczi K, Burack L, Pope M, et al. CD69, HLA- DR and the IL -2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry[J]. J Autoimmun, 2000, 14:63 -78.
  • 2Murakata H,Harabuchi Y,Kataura A et al. Increased interleukin26, interferon2gamma and tumour necrosis factor -alpha production by tonsillar mononuclear cells stimulated with alpha - streptococci in patients with pustulosis palmaris et plantaris [ J]. Acta Otolaryngol, 1999, 119 (3) : 384.
  • 3Bryan PP, Fred GW, Mark AG. Pathophysiology and treatmend of psoriasis [ J ]. AM J Heaith -Syst Pham, 2000, 57: 645.
  • 4Viemann D, GoebelerM, Schmid S, et al. Transcriptional profiling of IKK2/NF2B and p38 MAP kinasedependent gene exp ressionin TNF - stimulated primary human endothe - lial cells [ J ]. Blood, 2004, 103 : 3365 - 3373.
  • 5Hases I, Hobbe RM, RomeroMR, et al. Arole forrnitogen- activated protein kinase activation by integrine in the pathogenesis of psoriasis [ J]. J Clin Invest, 2001, 108(4) : 527 -536.
  • 6Krutamann J. Mechanisms of ultraviolet UVB and UVA phototherpy[J].J Investig Dermatol Symp Proc,1999,4:70-72.
  • 7Waiters IB, Ozawa M, Cardinale I, et al. Narrowband(312 -nm) UVB suppresses interferon gamma and interleukin 12 and increases IL-4 transcripts:differential regulation of cytokines at the single -cell level[ J]. Arch Dermatol, 2003,139 : 155 - 161.
  • 8Sigmundsdottir H, Johnston A, Gudjonsson JE, et al. Narrowband - UVB irradiation decreases the production of pro -inflammatory cytokines by stimulated T cells [ J ]. Arch Dermatol Res, 2005, 5:12.

同被引文献38

二级引证文献47

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部