摘要
麻醉狗注内毒素前左心血TXB_2/6-keto-PGF_(1α)及PAR均明显低于右心血;内毒素休克时,左、右心血TXB_2/6-keto—PGF_(1α)及PAR明显上升,且左、右心血之间的浓度梯度差消失;消炎痛明显减轻内毒素休克时的前述改变。注内毒素前及内毒素休克早期TXB_2/6-keto-PGF_(1α)与PAR之间呈显著正相关。结果提示:肺解聚功能与肺代谢TXA_2、PGI_2有关;内毒素休克早期,肺代谢TXA_2,PGI_2的失调是肺解聚功能受损原因之一。
This work attempted to investigate the mechanism of disturbance of pulmonary disaggregating function in ES. Three groups were studied: 1. saline group(n= 7); 2. E. Coli group (n=14); 3. indomethacine plus E. coli group (n=10). The plasma levels of TXB2,6 -keto-PGF1α and platelet aggregating ratio (PAR)in the blood from pulmonary arteries (PA) and left atria (LA)of the dog were measured at -30,0,2,5,15,60,120, and 240 min. The results showed that: the PAR and the TXB2/6 -keto-PGF1α ratio in the blood from LA were lower than that in the PA in group 1; the difference above mentioned disappeared in group 2 and were improved significantly in group 3; there was a significant positive correlation between PAR and the TXB2/6-keto-PGF1a ratio in the early stage of the ES and in the normal situation. Conclusions: 1. pulmonary disaggregating function may be related to metabolism of TXA2 and PGI2 in the lung; 2. this disturbance may be due to imbalance of the metabolism of TXA2, PGI2 in the lung.
出处
《湖南医科大学学报》
CSCD
1990年第4期317-322,共6页
Bulletin of Hunan Medical University
基金
国家自然科学基金
关键词
休克
脓毒性
血小板聚集
疾病模型
shock, saptic
respiratory distress syndrome, adult
platelet aggregation
dis- ease models, animal
physiopathology
dog
