摘要
为研究3′-大豆苷元磺酸钠(DSS)的体外抗氧化活性,测定了DSS对超氧自由基(O2-.)、羟基自由基(.OH)和1,1-二苯基-2-苦苯肼自由基(DPPH.)的清除能力,及其对Fe2+诱导的脂质过氧化反应和β-胡萝卜素/亚油酸自氧化体系的抑制作用。结果表明,DSS对DPPH.有一定的清除能力,对超氧自由基的清除能力较强,能很好地清除.OH自由基,对脂质过氧化有一定的抑制作用,对β-胡萝卜素/亚油酸自氧化体系有明显的抑制作用。说明DSS的药理作用可能与其较强的抗氧化能力有关。
The antioxidant activity of the 3′-daidzein sulfonate sodium （DSS） was investigated by employing several in vitro assay systems, including 1,1-diphenyl-2-picrylhydrazyl （ DPPH · ）/peroxide anion/hydroxyl radical-scavenging, peroxidation of polyunsaturated fatty acid from yolk lipoprotein induced by Fe^2 ＋ method, and β-carotene/linoleic acid assay system. DSS showed scavenging activity against free radicals such as DPPH · , peroxide anion and hydroxyl radicals. Furthermore, DSS exhibited powerful inhibitory effects on peroxidation of polyunsaturated fatty acid from yolk lipoprotein induced by Fe^2＋ and notable inhibitory effects on β-earotene/linoleie acid assay system at all the tested concentration levels. The results suggested that the biological functions of DSS might correlate with its powerful antioxidant activity.
出处
《天然产物研究与开发》
CAS
CSCD
2008年第4期698-700,680,共4页
Natural Product Research and Development
基金
国家自然科学基金(20175012)
