摘要
钨酸钠对油酸(OA)所致的大鼠肺损伤有明显保护作用,表现在肺系数,支气管肺泡灌洗液中嗜中性白细胞(PMN)和丙二醛、肺泡内RBC与PMN渗出比对照组显著降低;注入OA后5、15min的外周血中白细胞总数与PMN亦无明显下降。其机制可能与钨能抑制黄嘌呤氧化酶,使氧自由基产生减少有关。
The purpose of this study is to determine whether the source of oxygen free radicals (OFRs) is derived from xanthine oxidase(XO)in the pathogenesis of OA-induced rat lung injury or not. Two groups of rats, the OA+ tungsten(W) group (pretreated with W rich diet with sodium tungstate 0.7g/Kg and water with 100ppm for 3-4 weeks) and the OA grouop (as control) were observed. In comparison with control group the lung coefficient, the content of Malondi-aldehyde (MDA) and the count of neutrophils in bronchoalveolar lavage fluid, the amount of exuded RBC and neutrophil in pulmonary alveoli greatly decrea-ased . There was no decrease in the total number of WBC and the percentage of neutrophils in peripheral blood 5 or 15 minutes after injection of OA as the control group did. Tungsten is a relatively specific inhibitor to inactivate XO by interfering with its molybdnum-depended active site. It is suggested that OFRs which contribute to the OA-induced lung injury of rats might derive from XO rather than from PMN.
出处
《湖南医科大学学报》
CSCD
1990年第2期131-135,共5页
Bulletin of Hunan Medical University
基金
国家自然科学基金
关键词
氧自由基
肺损伤
钨
lung
oleic-acids
oxygen
free radicals
tungsten
molybdenum
malonates
xanthine oxidase
erythrocytes
neutrophils
rats
