摘要
【目的】观察曲美他嗪对老年冠心病慢性心力衰竭患者脑钠肽及心功能的影响。【方法】80岁以上老年冠心病患者68例,心功能在Ⅲ-Ⅳ级,随机分为曲美他嗪组(35人)和对照组(33人),对照组采用常规抗心衰治疗方法,曲美他嗪组在常规抗心衰治疗基础上加用曲美他嗪治疗,各组病人观察治疗12周,每组病人分别进行治疗前后血浆脑钠肽及心功能指标的测定。【结果】曲美他嗪组与对照组均能降低血浆脑钠肽水平,与对照组相比,曲美他嗪组下降更明显,差异有显著性(P<0.01);与对照组相比,曲美他嗪组能更有效的改善心功能(P<0.05)。【结论】在常规心衰治疗的基础上,加用曲美他嗪能显著降低血浆脑钠肽的水平,从而改善患者的心功能。
[Objective] To observe the effects of trimetazdine （TMZ） on Plasma brain natriuretic peptide levels （BNP） and cardiac function in the patients aged 80 and over with coronary heart disease. [Methods] A total of 68 patients were randomly divided into TMZ group and control group. TMZ group received TMZ （60 mg/d） and routine medications for 12 weeks, while control group only received routine medications during the same period. The BNP levels and cardiac function was determined before and after therapy. [Results] BNP levels was lower in two groups, There was significant difference between TMZ group and control group （ P 〈 0.01 ） . Compared with the control group, TMZ group can be more effective to improve the cardiac function （ P 〈 0.05） . [ Conclusions] In the basis of the traditional therapy on heart failure, plus TMZ can significantly reduce BNP levels, improve the cardiac function.
出处
《武警医学院学报》
CAS
2008年第10期883-884,892,共3页
Acta Academiae Medicinae CPAPF
关键词
曲美他嗪
老年
心力衰竭
脑钠肽
心功能
Trimetazidine
Elder
Heart failure
Brain natriuretic peptide
Cardiac Function
