端粒、端粒酶与细胞永生化
被引量：1
Telomere,Telomerase and Immortalization
摘要
永生化（immortalization）体外培养细胞自发或受外界因素的影响从增殖衰老危机中逃离．从而具有无限增殖能力的过程。自发永生化的几率非常小，啮齿类动物为10^-5～10^-6，而人类细胞则更为罕见．小于10^-12。目前研究发现细胞永生化与端粒和端粒酶有密切联系。端粒除保持染色体完整性外，还作为细胞生存期限的关键性调控因子存在．
出处
《口腔颌面外科杂志》
CAS
2008年第4期285-287,共3页
Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金项目(30772418)
关键词
端粒
端粒酶
永生化
telomere
telomerase
immortalization
参考文献20
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