摘要
目的观察高剂量复合螺旋藻多糖的辐射保护作用。方法高剂量(200 mg.kg-1.d-1)螺旋藻多糖与银杏叶有效成分按1∶1,2∶1和1∶2的比例复合。分别给昆明种小鼠灌服此3种复合制剂及螺旋藻多糖、银杏黄酮、银杏内酯3种单一成分。连续灌服14 d后,用60Coγ射线全身照射,照射后继续灌服16 d。结果与空白组相比,螺旋藻多糖与银杏叶有效成分1∶1比例复合组、2∶1比例复合组、1∶2比例复合组、螺旋藻多糖组、银杏黄酮组和银杏内酯组平均存活时间分别延长了2.3(P<0.05),2.5(P<0.01),2.6(P<0.01),4.0(P<0.01),3.7(P<0.01),3.3 d(P<0.01);存活率分别提高20%,30%,20%,80%,60%,40%。结论高剂量螺旋藻多糖与银杏叶有效成分复合应用于抗辐射有协同增效作用,可明显延长经60Coγ射线全身照射小鼠的存活时间,提高小鼠存活率。抗辐射作用优于螺旋藻多糖和银杏叶有效成分单一使用组。复合螺旋藻多糖的最佳配比为螺旋藻多糖与银杏叶有效成分等量复合。
Objective To observe the antiradiation effect of high dosage compound PSP. Methods Mixed high dosage（200 mg·kg^-1·d^-1） polysaeeharides from Spirulina Platensis （PSP） with effective ingredients of Ginkgo biloba（ EGB ） into the compound at the ratio of 1： 1,2： 1 and 1： 2, fed the mice with the compound and the single ingredients of PSP,flavonoids,ginkgolide for 14 days, then irradiated the mice with ^60Coγ radiation, after that fed them with the compound for consecutive 16 days. Restilts Compared with the control,the average living days of the mice in the groups fed with the compound at the ratio of 1： 1,2： 1,1 ： 2 and PSP,flavonoids, ginkgolide increased by 2.3 （ P 〈 0.05 ） ,2.5 （ P 〈 0.01 ） ,2.6 （ P 〈 0.01 ） ,4.0 （ P 〈 0.01 ） ,3.7 （ P 〈 0.01 ） ,3.3 d （ P 〈 0.01 ）. The living rates increased by 20% ,30%, 20%, 80% ,60% ,40%. Conclusion The results indicated that the compound with high dosage PSP and EGB has the synergic effects in the application of anti - radiation,which can obviously prolong the living days of mice with ^60Coγ radiation and enhance the livability. The anti - radiation action is better than any single effective ingredients of PSP and EGB. Compound with equal dosage of PSP and EGB is the best in the experiments of anti - radiation.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第8期1913-1914,共2页
Lishizhen Medicine and Materia Medica Research
基金
山东省青岛市科技发展计划(第2批)项目(No.06-2-2-12-jch)
青岛农业大学高层次人才启动基金资助项目(No.630432)
