摘要
目的：研究氢醌的亚慢性毒性。方法：ＳＤ大鼠５６只，雌雄各半，随机分成４组。分别用１５ｍｇ／ｋｇ、５０ｍｇ／ｋｇ、１５０ｍｇ／ｋｇ剂量的氢醌给予灌胃染毒，每天１次，每周５天，共３个月。结果：１５０ｍｇ／ｋｇ染毒组雄性大鼠体重增长减慢，肝、肾脏器系数及雌性大鼠肝脏器系数增高，骨髓有核细胞计数降低。各染毒组雌性大鼠血红蛋白有所降低，雌、雄性大鼠血小板计数随染毒剂量升高而降低，呈明显剂量－效应关系。肝、肾及免疫功能指标无明显改变。５０ｍｇ／ｋｇ、１５０ｍｇ／ｋｇ组个别大鼠有肝细胞轻度变性。结论：氢醌主要毒作用靶器官是血液系统，对肝、肾有非特异性的损害作用。血小板计数及血红蛋白定量是氢醌的毒作用的敏感指标，亚慢性毒作用的阈剂量为５０ｍｇ／ｋｇ。
bjective: To study subchronic toxicity of hydroquinone. Methods:Three-month gavage studies were conducted to evaluate the subchronic toxicity effects of repeated administration of hydroquinone on rats. 56 S.D. rats distributed to weight classes and assigned to dose groups according to a table of random numbers. Groups of 10 rats of each sex were administered 0,15,50, 150mg hydroquinone/kg by gavage, 5 days per week for three months. At the end of the three-month studies, rats were killed. A necropsy and histologic examinations were performed. Liver, kidney and immunity functions and bolld system were examined. Results: It showed that the rate of body weight growth of high dose (150 mg/kg) male rats were laggard. The relative organ weights of liver and kindey in male rats and those of liver in female rats were higher than those in control. High dose hydroquinone resulted in a significant loss in bone marrow hemogenesis. Platelet count were decreased in dosed rats; the doseeffect relationship was significant between the dose and platelet counts in rats. The immunity, live and kidney functions in rats were no changes significantly. The kidney and the liver cells of rats changed slightly. Conclusion: The main target organs of subchronic toxicity of hydroquinone were blood. The liver and kidney could be harmed nonspcifically. The sensible indexes were platelet count and hemoglobin. The threshold dose of subchronic toxicity was 50 mg/kg.
出处
《职业卫生与应急救援》
1997年第3期124-127,共4页
Occupational Health and Emergency Rescue
基金
中国预防医学科学院标准处委托研究
