摘要
目的研究血中胃泌素（GAS）、胃动素（MTL）水平在危重症及并发胃肠功能障碍患儿中的变化及意义。方法将75例患儿分为极危重组、危重组、非危重组，检测其急性期、恢复期及25例对照组血中GAS、MTL水平，分析GAS和MTL水平与病情危重程度、胃肠功能障碍的关系。结果极危重组、危重组、非危重组GAS分别为（227．41±62．80）、（154．25±38．84）、（84．01±17．10）ng／L，差异有非常显著性（P〈0．01）；MTL分别为（413．53±59．80）、（368．36±43．64）、（279．97±33．51）ng／L，差异有非常显著性（P〈0．01）。有胃肠功能障碍组血清GAS、血浆MTL水平明显高于无胃肠功能障碍组（P〈0．01）。极危重组、危重组患儿恢复期GAS、MTL水平低于急性期，差异有显著性（P〈0．01）。非危重组恢复期GAS、MTL水平与急性期比较，差异无显著性（P〉0．05）。结论血液GAS和MTL水平可作为检测胃肠功能障碍的实验室指标。
Objective To study the changes of serum gastrin and plasma motilin level in critical children with gastrointestinal dysfunction and to investigate its clinical significance. Methods Seventy-five cases were divided into extremely serious group, serious group and non-serious group. Serum gastrin and plasma motilin level were detected at acute stage and recovery stage. Serum gastrin and plasma motilin level of normal control group were detected on an empty stomach. Relationship between serum gastrin and plasma motilin level and gastrointestinal dysfunction as well as the disease severity were studied. Results Serum gastrin levels of extremely serious, serious and non-serious patients were （227.41 ± 62.80）, （154.25±38.84）, （84.01 ± 17.10） ng/L, showing a very significant difference （P 〈 0.01）;plasma motilin levels were （413.53 ± 59.80）, （368.36 ± 43.64）, （279.97 ± 33.51） ng/L respectively, also showing a very significant difference （ P 〈 0.01 ）. Serum gastrin and plasma motilin levels in patients with gastrointestinal dysfunction were significantly higher than those without gastrointestinal dysfunction （ P 〈 0.01 ）. For extremely serious patients and serious patients, serum gastrin and plasma motilin levels in recovery stage were significantly lower than those at acute stage （P 〈 0.01 ）. Serum gastrin and plasma motilin levels in non-serious patients showed no significantly difference between acute stage and recovery stage （ P 〉 0.05 ）. Conclusion Serum gastrin and plasma motilin level could be used as a laboratory marker for detecting gastrointestinal dysfunction.
出处
《中国小儿急救医学》
CAS
2008年第1期40-42,共3页
Chinese Pediatric Emergency Medicine
关键词
胃肠功能障碍
胃泌素
胃动素
Gastrointestinal dysfunction
Gastrin
Motilin
