摘要
用氟化钠做实验性氟中毒小鼠模型，然后灌服海尔福口服液１５天，检测粪氟排出量和骨氟排出量的变化。结果表明，服药组服药前粪便含氟量为３４７．２μｇ／ｇ，服药后为５１１．９μｇ／ｇ（ｘ），前后比较Ｐ＜０．０００１，差异有高度显著性；中毒对照组和正常对照组粪便含氟量分别为３８５．５和２０．０μｇ／ｇ（ｘ），两组比较Ｐ＜０．０００９，差异有高度显著性。正常对照组③、中毒对照组①和服药组②骨氟含量分别为２．５７、３５．１９、３３．１３μｇ／ｇ（ｘ），①与③、②与③比较Ｐ＜０．００１，差异有高度显著性，而①与②比较Ｐ＞０．０５，差异无显著性。提示海尔福口服液作用机理之一有可能是通过抑制氟中毒动物对氟的吸收而起治疗作用，而对骨氟的影响尚无明显。
The models of fluorosis mice carried with sodium fluoride. Then these mice were administered intragastrically with Haierfu oral liquor for 15 days and the fecal and skeletal fluorines were determinated. The results were following: In Haierfu group, the fecal fluorine was 34.7μg/g before taking medicine and it was 511.9μg/g() after taking medicine (P<0.0001). The fecal fluorine was 385.5μg/g in fluorosis group and it was 20.0μg/g() in normal control group (P<0.0009). The skeletal fluorine in normal control group. fluorosis group and Haierfu group was 2.57μg/g, 35.19μg/g and 33.13μg/g(), respectively. The skeletal fluorines in the last groups were not different (P>0.05). These suggested that one of the effective mechanism of Haierfu might be to inhibite the gastrointestinal tract to absorb the fluorine in fluorosis animals and it did not have much more influerce on skeletal fluorine.
出处
《右江民族医学院学报》
1997年第2期189-190,共2页
Journal of Youjiang Medical University for Nationalities
