摘要
目的探讨血清高敏C反应蛋白(hsCRP)水平与脑梗死病情及预后的关系。方法测定90例急性脑梗死患者入院时血清hsCRP含量,观察梗死灶大小不同、神经功能缺损程度不同时含量变化,应用美国国立卫生研究院卒中量表(NIHSS)及Barthel指数(BI)分别对患者入院时及治疗6个月后进行评分,并将血清hsCRP水平与NIHSS及BI评分进行相关性分析。同时选取80例健康体检人员血清hsCRP含量进行对照。结果脑梗死患者血清hsCRP含量明显高于健康对照组(P<0.01);脑梗死血清hsCRP水平越高,梗死灶越大,神经功能缺损程度越重;患者血清hsCRP水平与入院时NIHSS呈显著正相关(P<0.01),与6个月后BI评分呈显著负相关(P<0.01)。结论血清hsCRP水平是临床评价脑梗死严重程度和预后的一个重要生物学指标。
Objective To investigate the relationship between serum high sensitivity C-reactive protein（hsCRP） level and the severity and prognosis in cerebral infarction. Methods Ninety patients with acute cerebral infarction were evaluated by the volume of cerebral infarction and National Institutes of Health Stroke Scale（NIHSS） and Barthel index（BI） at admission and 6 months later. Serum hsCRP levels were measured at admission . Correlative analysis was performed among serum hsCRP level and NIHSS, BI scores. Eighty normal people in control group. Results The levels of hsCRP in cerebral infarction patients were marked higher than that in control group（P〈0. 05） ; Furthermore, the mean serum hsCRP levels were higher in patients had bigger volume of cerebral infarction and heavier neurological function defect; Serum hsCRP level was correlated significantly with NIHSS at admission and BI scores 6 months later（P〈0. 05）. Conclusion The serum hsCRP can be a sensitive index in the patients with cerebral infarction.
出处
《中国实用神经疾病杂志》
2008年第9期19-21,共3页
Chinese Journal of Practical Nervous Diseases
关键词
脑梗死
C反应蛋白
预后
Cerebral infarction
C-reactive protein
Prognosis
