摘要
目的:研究胃食管反流病食管外症状的食管酸暴露特点,探讨埃索美拉唑镁肠溶片对食管外症状的治疗价值。方法:32例具有食管外症状的GERD患者分成三组,异常酸反流组14例,食管对酸高敏组16例,功能性上腹灼痛组2例,并以埃索美拉唑镁肠溶片20mg,2次/d治疗8周。结果:异常酸反流组酸反流次数、长时间酸反流次数、pH<4,时间百分比较其他两组明显增加;食管对酸高敏组食管外症状指数显著高于功能性上腹灼痛组,P<0.05;治疗前食管对酸高敏组食管外症状积分明显高于异常酸反流组;治疗后4、8周,异常酸反流组、食管对酸高敏组的症状积分显著下降,而功能性上腹灼痛组患者仅有下降趋势,与治疗前比较差异无统计学意义(P>0.05)。埃索美拉唑镁肠溶片对GERD患者食管外症状4、8周治疗后的有效率分别为71%和80%。结论:食管对酸高敏患者可能更易发生食管外症状;埃索美拉唑镁肠溶片对GERD患者食管外症状有较好的治疗效果。
Objective To study the acid exposure characteristic of the extraesophageal symptoms of GERD and discuss the value of es. omeprazole treatment. Method Thirty - two cases of GERD with extroesophageal symptoms were subdivided into three groups ： 14 cases with abnormal acid reflux, 16 cases with acid hypersensitive oesophagus and the remaining 2 with functional heartburn. All the cases were treated with esomeprazole （20 mg, bid po） for 8 weeks. Results In the abnormal acid reflux group, the total degree of acid reflux, the degree of long reflux, the time percentage of pH 〈 4 were obviously increased as compared with the groups of acid hypersensitive oesophagus and functional heartburn; the symptom index of the group with acid hypersensitive oesophagus was apparently higher than that of the group of functional heartburn （P 〈 0.05 ）. The score extraesophageal symptoms in the acid hypersensitive oesophagus group was much higher than that in the abnormal acid reflux group before treatment （ P 〈 0.05）. The score of oesophageal symptoms in the abnormal acid reflux, and the acid hypersensitive oesophageal groups after treatment with esomeprazole for 4 and 8 weeks showed obvious decrease, while in the functional heartburn group the scores showed only a declining trend, but with no statistical significance. The total effective rate was 71% and 80% respectively after 4 weeks and 8 weeks of therapy. Conclusion The patients with hypersensitive oesophagus may be much more likely to suffer from extraesophageal symptoms. Esomeprazole has more effective treatment to extraesophageal symptoms of GERD.
出处
《吉林医学》
CAS
2008年第15期1252-1253,共2页
Jilin Medical Journal
