摘要
[目的]探讨谷胱甘肽-S-转移酶M1(GSTM1)基因多态性与原发性肝癌发病风险的关系。[方法]采用Meta分析方法对各研究进行合并效应值估计,进行敏感性分析、发表偏倚评估和累积Meta分析。[结果]共有国内外符合条件的13篇文献纳入分析,累计病例和对照数分别为1216和1685例。GSTM1空白基因型个体的原发性肝癌发病风险为非空白基因型个体的1.710倍(95%CI:1.307～2.236,P<0.05)。发表偏倚评估未发现明显的发表偏倚,敏感性分析显示Meta分析结果可信,累积Meta分析显示合并OR值随着时间推移和样本含量的增大而逐渐稳定。[结论]中国人群中GSTM1基因空白型的个体是原发性肝癌的易感人群。
[ Objective ] To investigate the relationship between Glutathione S-transferase M1 （ GSTM1 ） gene polymorphism and hepatic carcinoma risk in Chinese population. [ Methods ] Meta-analysis was performed to estimate the pooled odd ratio（ OR ） to assess the risk of hepatic carcinoma associated with GSTM1 deficiency. Random effect model or fixed effect model was used to calculate the pooled OR based on homogeneity test. Publication bias and sensitivity were evaluated. Cumulative Meta-analysis was used to evaluate whether the pooled OR for these studies was changing along with publication time or sample size. [ Results ] 13 studies with 1 216 cases and 1 685 controls were included for Meta-analysis based on inclusion criteria. Heterogeneity test indicated that 13 studies were not homogeneity（ P 〈 0.05 ）. The pooled OR of hepatic carcinoma risk associated with GSTM1 null genotype was 1.710 （ 95%CI： 1.307-2.236 ）estimated by random effect model. Publication bias was not significant in these studies. The results of Meta- analysis were credible by sensitivity analysis. Pooled OR was more stable by accumulation according to chronological order or sample size. [ Conclusion ] GSTM1 null genotype seems to be associated with the increased risk of hepatic carcinoma.
出处
《环境与职业医学》
CAS
北大核心
2008年第4期333-336,共4页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金(编号：30671740)
