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血红素氧化酶-1在冠心病患者中的表达

Clinical study on changes of heme oxygenase-1 expression in patients with coronary heart disease
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摘要 目的了解血红素氧化酶-1（HO—1）在冠心病患者中的表达情况。方法对84例经冠状动脉造影确诊为冠心病的病例进行研究，其中急性心肌梗死35例，非急性心肌梗死49例，同时选择46例非冠心病病人作为正常对照组，采用Westem blot印迹方法，测定研究组与对照组病例外周血单个核细胞中血红素氧化酶-1的表达强度，并进行对照分析。结果冠心病组中急性心肌梗死病例与非急性心肌梗死病例，以及非冠心病组之间的HO—1表达强度存在显著差异。结论HO—1的表达强度与冠心病的严重程度存在相关性。 Objective To explore the express intensity of Heme Oxygenase-1（HO-1）on coronary heart disease patient（CHD）.Methods study group is 84 cases with CHD （35 cases with acute myocardial infarction, 49 cases without acute myocardial infarction） was diagnosed by coro- nary angiography, and. the 46 cases without Coronary Heart Disease is control group, Using Westem blot marking it is measured that the expressed HO-1 in the mononuclear cell of peripheral vessel＇s blood and compared, study group with normal control group. Results the defference of expression of HO-1 was highly significant among acute myocardial infarction, without acute myocardial infarction, and control group （P〈0.01）.Conclusion The relation between the express intensity of HO-1 and serious of CHD.
作者 陈润钿 黄婷 陈军 卓金旋
机构地区 佛山市第一人民医院
出处 《国际医药卫生导报》 2008年第18期9-11,共3页 International Medicine and Health Guidance News
基金 2005年佛山市科技攻关项目（医药卫生类）（编号：200508021）
关键词 血红素氧化酶-1 冠心病 Heme Oxygenase-1 Coronary Heart Disease
分类号 R541 [医药卫生—心血管疾病]
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参考文献6

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二级参考文献21

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国际医药卫生导报
2008年 第18期

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