摘要
目的通过检测GD患者外周血血清中IL-6、IL-10、IFN-γ三种细胞因子水平于治疗前后的变化及关系,探讨其与甲状腺功能变化的相关性及临床意义。方法取GD患者共32例,缓解期患者组共33例为确诊的GD患者,接受系统抗甲状腺药物治疗,临床症状缓解,甲状腺功能恢复正常者定为缓解组。以上两组患者均无其它自身免疫性疾病和感染性疾病。另取正常健康人40例,均无甲状腺疾病史及甲状腺疾病家族史定为正常对照组。取所有受试者静脉血测定FT3、FT4、TSH、TMAb、TGAb、IL-6、IL-10、IFN-γ值。结果IL-6:GD组较缓解组显著增高(P<0.01),缓解组与对照组无明显差异(P>0.05)IL-10:GD组与缓解组较对照组显著增高(P<0.01),GD组与缓解组无明显差异(P>0.05)IFN-:γGD组与缓解组较对照组显著增高(P<0.01),GD组与缓解组无明显差异。结论IFN-γ可诱导甲状腺细胞Ⅱ型抗原的表达,进而增强这些细胞的免疫原性。IFN-γ单独或与TNF-α联合作用可促进甲状腺细胞表达胞间粘附分子Ⅱ(ICAM-Ⅱ)及HLA-Ⅱ类抗原,并且TNF-α可增强IFN-γ对TEC的MHC-Ⅱ分子抗原的高效表达,而表达的异常则可使自身免疫反应得以发生及进行性发展。随治疗过程的进展,IFN-γ仍处于较高水平,高于正常对照组,反映了免疫治疗过程的滞后性。
Purpose Use the way of testing the change and relation of GD patients＇ IL - 6 ,IL - 10 ,IFN - γ in Outside cycle blood Serum before and after treating, to discuss their correlativity and clinic significance with the Thyroid gland＇s function change. Method Take 32 GD patients for GD Team, and 33 definitely diagnosed GD patients, who accept anti-Thyroid gland drug treatment in system, clinic symptom are relieved, and Thyroid gland function return to normal is Relieved Team. There is either autoimmunity diseases or Infectious diseases in both two teams. And take 40 healthy persons who either have Thyroid gland disease history or Thyroid gland disease clan history for Normal Contrast Team. Take all tested persons＇ Vein blood to test the FT3 、FT4 ,TSH,TMAb,TGAb,IL - 6,IL - 10,IFN - γ. Result IL - 6： GD Team is much higher than Relieved Team （P 〈 0.01 ）, there is no remarkable difference between Relieved Team and Contrast Team （P 〉 0. 05 ）. IL - 10 ： GD Team and Relieved Team are both much higher than Contrast Team （ P 〈 0.01 ）, there is no reamarkable difference between GD Team and Relieved Team. Conclusion IFN - γ can guide Thyroid gland cell Ⅱ style Antigen＇s express, then to strengthen these ceils＇ immunogenicity. IFN - γ alone or effected with TNF - α can promote Thyroid gland cell to express in cell glue molecule Ⅱ （ ICM - Ⅱ ） and ttLA - Ⅱ antigen, and TNF - α can strengthen IFN - γ＇s high-effect express to MHC - Ⅱ Molecule antigen of TEC, and the extraordinary express can make autoimmune response to arises progressivity development. With the progress of treatment, IFN - γ is still in a high level, higher than Contrast Team, reported the Lagging of immunotherapy process.
出处
《世界科技研究与发展》
CSCD
2008年第4期483-484,共2页
World Sci-Tech R&D
