摘要
目的探讨血清降钙素原(PCT)在小儿肾病综合征复发中的意义。方法将我院收治的原发性肾病综合征复发的患儿分为三组即合并细菌感染组50例、合并病毒感染组32例及非感染组16例,采用免疫色谱法,分别测定三组患儿的血清PCT,同时测定C反应蛋白(CRP)、中性粒细胞碱性磷酸酶(NAP)及外周血白细胞(WBC)计数。结果细菌感染组血清PCT阳性率(84%)高于非感染感染组(12.5%)和病毒感染组(0%),差异均具有非常显著统计学意义(P<0.01)。细菌感染组血清CRP阳性率(76%)高于非感染感染组(37.5%)和病毒感染组(0%),差异均具有非常显著统计学意义(P<0.01)。细菌感染组血清NAP阳性率(78%)高于非感染感染组(31.3%)和病毒感染组(12.5%),差异均具有非常显著统计学意义(P<0.01)。细菌感染组WBC计数均值高于非感染感染组和病毒感染组,差异均具有非常显著统计学意义(P<0.01)。在细菌感染组,血清PCT检测阳性率高于CRP、NAP检测阳性率,差异具有统计学意义(P<0.05)。结论血清PCT检测可应用于肾病综合征复发患儿,作为早期快速鉴别细菌感染的实验室新指标,以明确肾病复发的原因,指导抗生素的使用。
Objective To evaluate the significance of serum procalcitonin （PCT） in discriminating the reason of relapse of nephrotic syndrome in children. Methods In 50 cases of childhood nephretic syndrome with bacterial infection ,48 cases with viral infection and 16 cases without infection, serum PCT levels, C-reactive protein （CRP） levels, and alkaline phosphatase of neutrephilic granulocyte （NAP） levels,were detected by immunochromatography. Peripheral white blood cells（WBC） were counted in three groups. Results The positive rate of PCT in patients with bacterial infection was significantly higher than that in patients with viral infection or without infection （ P 〈 0. 01 ） ,the positive rate of CRP in patients with bacterial infection was significantly higher than that in patients with viral infection or without infection （ P 〈 0.01 ）. The positive rate of NAP in patients with bacterial infection was significantly higher than that in patients with viral infection or without infection（ P 〈0. 01 ）. The mean of WBC in patiens with bacterial infection was significantly higher than that with viral infection or without infection（ P 〈 0. 01 ）. In bacterial infection group, the positive rate of PCT was significantly higher than the positive rate of CRP or NAP. Conclusions PCT could be proposed as one of important differential marker in the relapse of childhood nephrotic syndrome. It is an early and rapid new differentiation test for bacterial infection, and can help us to find the reason of the relapse of nephretic syndrome, then give the guidance to the use of antibiotics.
出处
《世界科技研究与发展》
CSCD
2008年第4期480-482,共3页
World Sci-Tech R&D
基金
山东大学卫生局科技项目资助(2003B62)
关键词
降钙素原
肾病综合征
复发
细菌感染
procalcitonin
nephrotic syndrome
relapse
bacterial infection
