摘要
[目的]为比较不同溶剂在链脲佐菌素血糖模型的作用。[方法]采用pH4.5柠檬酸PBS(A组)、pH5.5Hanks(B组)、pH7.0 Hanks(C组)、pH7.0生理盐水(D组)4种溶剂,溶解链脲佐菌素小鼠腹腔注射,观察溶剂及其酸碱度对模型的影响。[结果]pH4.5柠檬酸PBS造模成功率高达86.7%,pH4.5柠檬酸PBS可以作为理想的溶剂。[结论]酸性溶液成模率高。
[Objective] To compare the different solvent in streptozotocin （STZ） blood sugar model in mice. [Methods] Four solvents, pH4.5 citric acid PBS （A group）, pH5.5Hanks （B group）, pH7.0Hanks （C group）, pH7.0 brine （Dgroup） solved STZ then carried out peritoneal injection to mice. Blood sugar was measured. [Results] pH4.5 citric acid PBS group had the highest achievement ratio of forming the model. [Conclusions] Acid solvent has high achievement ratio of forming diabetes model.
出处
《现代预防医学》
CAS
北大核心
2008年第17期3454-3455,共2页
Modern Preventive Medicine
