摘要
肝纤维化是继发于各种形式慢性肝损伤之后的组织修复过程中的代偿反应，它也是慢性肝病发展为肝硬化的必经病理过程。各种病因所引起的慢性肝病绝大多数都有肝纤维化，其中25％～40％最终发展为肝硬化乃至肝癌。因此，肝纤维化的发生机制成为目前慢性肝病的研究热点之一。肝纤维化的形成是一个多因素、多细胞参与的复杂过程。涉及多种细胞因子和蛋白成分表达的改变，细胞因子在肝星形细胞的活化、表型改变中扮演重要角色。此文对部分细胞因子在肝纤维化中的作用作一简要综述。
Liver fibrosis is induced by the compensatory react of hepatic tissue renovation after all kinds of chronic hepatic injuries, and is also an essential phase of liver cirrhosis. Many chronic hepalie injuries develop into liver fibrosis, cirrhosis, even hepatocellular carcinoma. Aeeordingly, the mechanism of liver fibrosis has become an investigative hot spot of chronic liver disease. Liver fibrosis formation is a complex process with multiple factors and many cells, which includes the changes of many eytokines and express of protein component. Cytokines play a eonsiderable role in hepatic stellate cells aetiveation and shape alteration. The research gives a simple summary about the effect of some cytokines in liver fibrosis.
出处
《国际流行病学传染病学杂志》
CAS
2008年第4期285-287,共3页
International Journal of Epidemiology and Infectious Disease
关键词
肝硬化
细胞因子
结缔组织
肝星形细胞
Liver cirrhosis
Cytokines
Connective tissues
Hepatic satellate cells
