摘要
目的观察卡维地洛治疗慢性心力衰竭（CHF）后对患者血浆脑钠肽（BNP）的影响。方法86例慢性心力衰竭心功能在Ⅱ～Ⅳ级患者，在常规心力衰竭治疗基础上，加用卡维地洛，观察治疗前后BNP水平变化。结果血压下降，心率减慢，心胸比缩小．左室舒张朱期内径（LVDd）缩短，左室射血分数（LVEF）提高，BNP水平显著降低。结论卡维地洛治疗慢性心力衰竭（CHF）可使BNP值明显下降，增加LVEF，缩小左室内径，改善心功能，BNP水平与LVEF呈显著负相关，可作为诊断心衰和了解预后的指标。
Objective To observe plasma brain nutriuretic peptide level of patient with congestive heart failure （CHF） treated with low dose Carvedilol. Methods Chose 86 heart failure patients with Ⅱ-Ⅳ New York Heart Association （NYHA） functional classification, and used carvedilol on the basis of traditional treatment, then observe the change in the plasma brain natriuretic peptide level during the treatment. Results After the treatment, patients＇ heart rate, blood pressure, cardio-thoracic ratio and LVDd all defined,but LVEF increased. The value of BNP declined significantly. Conclusion The value of BNP declined obviously after the use of carvedilol, which may help to increase LVEF, reduce the left ventricular diameter and improve the heart function. BNP level presented a negative correlation with LVEF, which can be used as index for diagnosis and prediction.
出处
《当代医学》
2008年第6期68-69,共2页
Contemporary Medicine
