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子痫前期孕妇血清氧化低密度脂蛋白及脂联素的水平变化及临床意义

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摘要 目的探讨氧化低密度脂蛋白(oxLDL)水平和脂联素(adiponec-tin)水平在子痫前期(PE)患者血清中的变化及其意义。方法45例PE患者,并分子痫前期轻度(MPE)25例,子痫前期重度(SPE)20例,采用酶联免疫吸附(ELISA)法检测血清中oxLDL和脂联素水平,并记录孕妇入院时的血压;随机选取同期50例正常妊娠孕妇作为对照组。结果SPE组血清中oxLDL水平显著高于对照组和MPE组,差异有统计学意义(P〈0.01或P〈0.05);三组间血清脂联素水平差异无统计学意义(P〉0.05),但对照组、MPE组、SPE组依次呈现下降趋势;SPE组孕妇血清oxLDL水平与收缩压、舒张压的变化呈正相关,相关系数r分别为0.50、0.45;SPE组孕妇血清脂联素水平与收缩压、舒张压的蛮化呈彘相关.相关系数r分别为-0.47、-0.40。结论血清中oxLPL和脂联素的水平蛮化可能与PE发病及其病情相关。
作者 陈友好
出处 《当代医学》 2008年第6期1-2,共2页 Contemporary Medicine
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