摘要
乙型肝炎病毒(HBV)慢性感染是我国肝细胞肝癌(HCC)发生的主要原因之一。在HBV感染所致的肝癌中,乙型肝炎病毒x基因HBxAg起着重要的作用。HBxAg是一种反式激活蛋白,与宿主的许多蛋白相互作用,调节基因的转录、表达,进而影响病毒的复制、宿主细胞信号转导、细胞增殖与分化、细胞凋亡及癌变等。本文通过总结HBxAg与已知癌基因ras、c-myc、c-fos、c-jun、β-catenin,抑癌基因p16、p21、p53的研究进展,以及近年来新发现的一些HBxAg相关癌基因:URG11、URG4、URG7、Human S15a、Sui1、VEGFR3、XTP3、XTP4、XTP6、XTP11与HBxAg的关系对HBxAg反式激活癌基因异常表达与肝细胞癌的研究现状进行综述。
Chronic infection of Hepatitis B Virus （HBV） is one of the major causes of hepatocellular carcinoma （HCC） in our country. During the process of HBV infection, x antigen of Hepatitis B virus （HBxAg） plays a crucial role in the development of hepatocellular carcinoma（HCC）. HBxAg is a trans-activating protein which modulates gene transcription,expression through interaction with a variety of host proteins. Furthermore, HBx shows extensive effect on viral replication, host cell signal transduction, cell proliferation and differentiation, apoptosis, and involves in carcinogenesis. This article not only reviews some researchs on the interaction between HBx and many known genes,such as ras, c- myc, c-fos, c-jun, β-catenin, p16, p21, p53, but also other new genes discovered recently, which are URG11, URG4, URGT, Human S15a, Suil, VEGFR3, XTP3, XTP4, XTP6, XTP11.
出处
《胃肠病学和肝病学杂志》
CAS
2008年第8期688-692,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金资助(30371790)
广东省自然科学基金资助(C03050301)
深圳市科技项目资助(200304145)
关键词
HCC
HBXAG
反式激活
Hepatocellular carcinoma
Hepatitis B x antigen
Trans-activation
