摘要
目的:观察淫羊藿苷对铝诱导的痴呆大鼠模型学习记忆的影响,并分析其作用机制。方法:以三氯化铝溶液诱导痴呆大鼠模型,采用Morris水迷宫检测大鼠的空间辨别学习记忆能力及化学法检测大脑皮层及海马Na+-K+-ATPase和Ca2+-ATPase活性。结果:淫羊藿苷可缩短痴呆大鼠在定向航行实验中逃避潜伏期及搜索距离,并增强鼠脑皮层及海马Na+-K+-ATPase、Ca2+-ATPase活性。结论:淫羊藿苷对铝盐诱导的痴呆大鼠学习记忆障碍模型有保护作用,其机制至少与增加大鼠脑内Na+-K+-AT-Pase、Ca2+-ATPase活性有关。
Objective： To investigate the protective effects of icariin （Ica） on learning and memory deficits induced by aluminum, and explore its potential mechanisms in rats. Methods： The dementia model in rats were induced by drinking of 1600 ppm AICI3 solution all the time, and the ability of spatial learning and memory was tested by Morris water maze per month. The activities Na ^＋ -K ^＋-ATPase and Ca^2＋ -ATPase in cerebral cortices and hippocampus were assayed by their corresponding reagent kits, respectively. Results： Ica significantly protected against aluminum-induced dementia model, as evidenced by decreased escape latency and searching distance compared with the model control group. The activities of Na ^＋ -K ^＋ -ATPase and Ca^2＋ -ATPase in Ica-treated groups were significantly increased compared with the model control group. Conclusion： Ica can protect against dementia induced by aluminum, at least the mechanisms may be increase the activity of Na＋ _K＋ -AT- Pase and Ca^2＋-ATPase in rat brain.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2008年第3期24-25,共2页
Pharmacology and Clinics of Chinese Materia Medica
基金
贵州省科技厅资助[黔科合计(2003)016]
