摘要
背景；课题设计基于前期工作已研究了去势致骨质疏松动物骨的拉伸、剪切、力学性能和粘弹性力学性质的条件下进行。目的：进一步观察正常大鼠和去势后骨质疏松大鼠椎骨的压缩、弯曲、扭转和冲击力学性质。设计、时间及地点：随机对照动物实验，于2006-01／2007—01在吉林大学力学实验中心完成。材料：选用280～320g，四五月龄Wistar雌性大鼠86只，随机分为正常对照组43只，模型组43只。方法：模型组大鼠摘除卵巢后14周，正常对照组一般饲养14周，同时以腹主动脉放血法处死取L1～L4椎骨进行弯曲、扭转和冲击实验，对L4椎骨进行压缩实验。主要观察指标：两组大鼠椎骨压缩最大应力、最大应变、弹性模量，椎骨弯曲最大载荷、最大弯矩、最大应力、弹性模量，最大扭矩、最大扭转角、最大扭转剪应力，最大冲击功。结果：模型组压缩应力、应变、弹性模量低于正常对照组（P〈0．05）。模型组弯曲弹性模量、弯矩、弯曲应力低于正常对照组（P〈0．05）。模型组扭矩、扭转角、扭转剪应力低于正常对照组（P〈0．05）。模型组冲击功、冲击韧性低于正常对照组（P〈0．05）。结论：去势法制作的骨质疏松模型弯曲、扭转、压缩和冲击力学性能均降低说明骨质疏松后骨纤维结构的强度和韧性降低。
BACKGROUND： Extension, shearing, mechanical function and viscoelastic properties have been studied in previous studies in animals of osteoporosis induced by ovariectomy. OBJECTIVE： To further investigate osseous compression, bending, torsion and impulsion in normal rats and osteoporotic rats induced by ovariectomy. DESIGN, TIME AND SETTING： The randomized control animal experiment was performed at the Mechanical Experimental Center of Jilin University from January 2006 to January 2007. MATERIALS： Totally 86 female Wistar rats aged 4-5 months weighing 280-320 g were randomly divided into a normal control group （n=43） and a model group （n--43）. METHODS： Rats in the model group 14 weeks after ovariectomy and rats in the normal control group 14 weeks after raising were sacrificed by abdominal aorta depletion method to obtain L1-L4 vertebrae for bending, torsion and impulsion. L4 vertebrae received compression. MAIN OUTCOME MEASURES： Maximum stress, maximum strain, modulus of elasticity of compression on rat vertebrae; bending loading, bending moment, bending stress, modulus of elasticity and torque, angle of torsion, shear stress of torsion and impact energy of rat vertebrae in both groups. RESULTS： Compressive stress, strain and modulus of elasticity were lower in the model group than in the normal control group （P 〈 0.05）. Bending modulus of elasticity, bending moment and bending stress were lower in the model group than in the normal control group （P 〈 0.05）. Torque, angle of torsion, shear stress of torsion were lower in the model group than in the normal control group （P 〈 0.05）. Impact energy and toughness were lower in the model group than in the normal control group （P 〈 0.05）. CONCLUSION： The bending, torsion, compression and impulsion decrease in the osteoporotic models after ovariectomy, which indicates that the bone fiber strength and toughness reduce after osteoporosis.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第33期6466-6469,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
