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N-乙酰半胱氨酸对烟雾暴露所致大鼠慢性阻塞性肺疾病模型的影响 被引量：1

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摘要 血管内皮细胞生长因子（VEGF）对于维持正常肺泡结构、抗损伤及组织修复、抗内皮细胞凋亡具有重要作用，关于抗氧化剂对COPD肺组织VEGF分泌及间隔细胞凋亡影响的研究鲜有报道。我们采用熏香烟法建立大鼠COPD模型，通过N-乙酰半胱氨酸（NAC）干预，观察其对大鼠肺功能、肺气肿程度和肺泡间隔细胞凋亡及VEGF分泌的影响，了解COPD发病机制中氧化和抗氧化失衡与凋亡之间的关系。
作者 蔡珊 陈平 张程 陈剑波 吴杰 罗曼
机构地区 中南大学湘雅二医院呼吸科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2008年第8期623-624,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 国家自然科学基金资助项目（30770931） 教育部高等学校博士学科点专项科研基金资助项目（20050533023） 湖南省研究生创新工程专项经费资助项目（2006116）
关键词 N-乙酰半胱氨酸 慢性阻塞性肺疾病模型 大鼠 烟雾暴露 血管内皮细胞生长因子 内皮细胞凋亡 COPD VEGF
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献7

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二级参考文献15

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共引文献30

同被引文献21

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二级引证文献9

中华结核和呼吸杂志
2008年 第8期

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