摘要
目的观察大黄对多发伤合并休克兔肝、小肠的保护作用。方法纯种大白兔24只,复制多发性创伤合并休克兔的模型,随机分为三组:治疗组(常规治疗+大黄治疗组),对照组(常规治疗+安慰治疗组),假手术组,每组8只。复苏24h后处死动物,取肝、小肠行病理检查,并测量细胞线粒体二维平面形态计量学参数和三维平面形态计量学参数。结果治疗组肝及小肠粘膜病理损害的程度较对照组明显减轻,细胞单位胞浆内治疗组比对照组线粒体数量多,肿胀较轻微。结论大黄能减轻多发伤合并休克后肝、小肠病理改变,大黄对多发伤合并休克模型兔肝、小肠损伤有显著保护作用。
Objective To observe the protective effect of Rhubarb on liver and small intestinal in multiple traumatic rabbits with complicating shock. Methods Twenty four rabbits were randomly divided into 3 groups, 8 in each group, namely sham operation group, treatment with Rhubarb group（treatment group）,treatment with normal saline group（control group）, multiple traumatic rabbits with complicating shock animal model was established according to the Chen＇s method. 24 hours after seriously multiple trauma the animals were killed. Liver and small intestinal epithelial tissues were obtained for microscopic examination. The two-dimensional structural parameters and three-dimensional structural parameters of mitochondria were calculated. Results obvious pathologic lesions of the organs were seen in control group. But in treatment group, there were less pathologic lesions of the organs, and in sham operation group, there weren＇t obviously pathologic lesions of the organs. Structural parameters of mitochondria： In control group, there were the least mitochondria and the swelling of mitochondria was severe. In treatment group, the mitochondria were more than that of control group and the swelling were slight. Conclusions Rhubarb can obviously protect liver and small intestine from seriously multiple traumatic rabbits with complicating shock.
出处
《合肥医学院学报》
2008年第3期233-237,共5页
Journal of Zunyi Medical University
关键词
大黄
多发性创伤
休克
内脏
病理改变
Rhubarb
multiple trauma
shock
viscera
pathological change
