摘要
目的探讨2型糖尿病患者中C-反应蛋白(CRP)与糖尿病视网膜病变(DR)的关系。方法速粒散射比法测定48例糖尿病无DR对照组、48例糖尿病DR患者的血清CRP、HbAlt水平,比较组间差异及血清CRP、HbAlt水平与DR病变程度的相关性。结果DR组的血清CRP水平高于对照组,差异有显著性(P<0.05);CRP、HbAlt水平在DRⅠ期、Ⅱ期、Ⅲ期、Ⅳ期组逐渐增高,差异有显著性(P<0.05)CRP、HbAlt水平与DR病变程度呈正相关。结论CRP水平在对照组、DRⅠ期、Ⅱ期、Ⅲ期、Ⅳ期组逐渐增高,表明其可能是2型DM患者DR发生、发展的危险因素;在一定程度上能够预侧2型糖尿病患者发生DR的风险并估计其严重程度。
Objective To clarify the relationship between C-reactive protein （CRP） and diabetic retinopathy. Methods We assayed serum CRP concentration and HbAlc in 48 diabetes patients without DR controls and 48 trpe 2 diabetes patients with DR （9 stage Ⅰ ,15stage Ⅱ ,17 stage Ⅲ,7 stage Ⅳ）.Results CRP concentration was higher in DR group than control（P 〈 0.05）,CRP concentration rise with DR stage （ P 〈 0.05）, highest in stage Ⅳ DR. Conclusion Higher serum CRP concentration in patients of DM and DR may be a risk factor that give rise to DM and DR. CRP, to some extent,could predict the oceuremce risk of DR in type 2 diabetic patients.
出处
《中国实验诊断学》
2008年第8期990-992,共3页
Chinese Journal of Laboratory Diagnosis
