摘要
目的研究抑癌基因PTEN在宫颈癌组织中的表达,探讨PTEN与宫颈癌临床及病理特征的关系。方法应用免疫组织化学方法(SP法)检测PTEN基因在46例宫颈癌组织中的表达。结果46例宫颈癌组织中,PTEN阳性表达率为36.9%,其中在高、中、低分化宫颈癌中的阳性表达率分别为55.6%、41.7%和25.0%,PTEN阳性表达率与宫颈癌病理学类型和患者年龄无相关性(P>0.05);临床分期Ⅰ期和Ⅱ期及以上者阳性表达率分别为58.8%和24.1%(P<0.05);有、无淋巴结转移者的阳性表达率分别为23.1%和42.4%(P<0.01);在直径<4cm或≥4cm的宫颈癌组织中的阳性表达率分别为23.1%和55.0%(P<0.05);结论PTEN异常表达可能与宫颈癌发生、发展及预后有关。
Objective To investigate the expression of PTEN gene in human cervical cancer and clarify the relationship between the expression of PTEN gene and the clinical and pathological features of cervical cancer. Methods The expression of PTEN in 46 samples of cervical cancer tissues were detected by immunohistoehemistry streptavidin - perosidase （SP） method. Results The positive expression rate of PTEN in cervical cancer tissues was 36.96%. The positive rate in the high, middle and low pathohistologie grading was 55.56% , 41.7% and 25.0%. The expression of PEN was not correlated with the cervical cancer pathologic types and patients＇ ages （ P 〉 0.05, respectively）. The positive rate in clinical cancer stages Ⅰ and ≥Ⅱ a was 58.8% and 24.1% （ P 〈 0.05 ） , 42.4% of the cases without and 23.1% of the cases with lymph node metastas showed positive for PTEN （P 〈 0.01 ）. In cancerous focus size 〈 4cm and ≥ 4cm, the positive rate of PTEN was 55.0% and 23.1% （ P 〈 0.05 ）. Conclusion The abnormal expression of PTEN may be assoieated with the tumorigenesis, development, prognosis of cervical cancer.
出处
《中国热带医学》
CAS
2008年第9期1507-1508,共2页
China Tropical Medicine
关键词
PTEN
宫颈癌
基因表达
PTEN
Cervical cancer
Expression of gene
