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螺内酯片临床药动学和生物等效性研究 被引量:3

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摘要 20例健康受试者随机交叉口服被试制剂与参比制剂200 mg。采用HPLC法测定血浆中螺内酯的代谢物坎利酮的浓度。发现参比制剂与被试制剂的体内过程均符合一房室开放模型,主要药动学参数AUC0t、AUC0∞、Cmax、Tmax均无明显差异,提示本文方法适用于螺内酯的人体药动学研究,两种制剂具有生物等效性。
出处 《山东医药》 CAS 北大核心 2008年第19期76-78,共3页 Shandong Medical Journal
基金 新药药动学和生物等效性研究(省部委基金)
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